Genetics of Antigen Receptors and V(D)J Recombination

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10 Terms

1
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How are BCR and TCR variable regions encoded?

By rearranged gene segments

2
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Which gene segments encode heavy chains?

V, D and J

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Which gene segments encode light chains?

V and J

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What enzyme complex mediates recombination?

V(D)J recombinase

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Which genes encode recombinase components?

RAG-1 and RAG-2

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What type of DNA repair is used?

Non-homolgous end joining

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Where does Ig gene rearrangement occur?

Bone marrow

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What happens if RAG genes are mutated?

Immunodeficiency

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Why is heavy chain rearrangement first?

It is required before light chain rearrangement

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What ensures each lymphocyte has a unique receptor?

Random gene segment recombination