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central nervous system location
brain and spinal cord
peripheral nervous system
neurons outside the CNS, sensory division and motor division
general nervous system functions
receiving input and transmitting signals to an integrating center (sensory)
control of the internal environment by sending signals to effector organs (automatic)
voluntary control of movement (somatic)
assimilation of experiences (CNS)
cell body
main cellular structures with nucleus and organelles
dendrites
conduct nerve impulses toward the cell body
axon
conducts impulses away from the cell body, may be covered by adipose-like Schwann cells
synapse
gap between the axon of one neuron (pre-synaptic neuron) and dendrite of another (post-synaptic neuron)
all or none law
if a nerve is stimulated and reaches its threshold it will cause a nerve impulse/action potential, the strength of the impulse is the same no matter what the magnitude of the stimulation
reaching threshold: neurotransmitters
neurons communicate across small gaps, or synapses, using chemical neurotransmitters
general types or responses or neurotransmitters
excitatory or stimulatory: help post-synaptic cell to reach its threshold
inhibitory: hinders post-synaptic cell reaching its threshold
reaching a neuron's threshold is determined by the summation of all output
proprioceptors
provide CNS with information about body position and movement
vestibular receptors
a type of proprioceptor, found in the nonauditory portion of the inner ear, provides CNS with head/body position info
kinesthetic receptors (mechanoreceptors)
a type of proprioceptor, muscle spindles, Golgi tendon organs, free nerve endings. provide the CNS with information on movement
chemoreceptor
provide CNS with information regarding the metabolic rate and muscular activity
baroreceptors
provide CNS with information regarding pressure, such as blood pressure
muscle spindles: a mechanoreceptor
special muscle fibers and sensory neurons located in a connective sheath within the muscle. detects changes in muscle length, rate of length change, and accounts for stretch (myotonic) reflex
nervous system reflexes
rapid, unconscious means of reacting to stimuli
stretch or myotonic reflex
two neuron reflex, one sensory (afferent) and one motor (efferent) neuron, protective reflex
Golgi tendon organ (GTO): a mechanoreceptor
sensory neurons located in the muscle tendon (extension of muscle's connective tissues), monitors tension developed in the whole muscle, excessive force generation results in some muscle fibers
somatic motor function: motor neurons of PNS
carry neural messages from spinal cord to skeletal muscles
somatic motor function: motor unit
a single motor neuron and all the muscle fibers it innervates
somatic motor function: innervation ratio
number of muscle fibers per motor neuron: 1:10s in the eyeball where fine control is required, 1:1000s in the larger muscles that control gross movements
motor cortex
part of the cerebral cortex, most concerned with voluntary movement, forwards message down spinal column to muscles
cerebellum
coordinates sensory information on complex movements, balance, and body position, considered to modify muscular activity
autonomic nervous system
assists in maintaining the internal environment, organs and tissues not under voluntary control, collaborates with the endocrine system
autonomic NS controls several types of tissues
smooth muscle, cardiac muscle, and glands
how many neurons to get to the tissues?
two, a pre and a post-synaptic neuron
autonomic nervous system: sympathetic division
usually excites an effector organ, thoracic and lumbar regions of the spinal cord, pre-synaptic neurons release acetylcholine, post-synaptic neurons release norepinephrine
autonomic nervous system: parasympathetic division
usually inhibits an effector organ, cranial and sacral spinal cord, pre- and post-synaptic neurons releases acetylcholine
skeletal muscle tissues
striated muscle, voluntary control, can be controlled by autonomic nervous system
cardiac muscle tissues
striated muscle, involuntary
smooth muscle tissues
non-striated muscle, involuntary (GI tract, arteries, veins)
structure of skeletal muscle
long, cylindrical cell/fibers, cross-striations of alternating light and dark bands, up to several hundred nuclei in each cell/fiber, structural independence from each neighboring fiber (fibers contract without the fiber next to it contracting)
nervous system control of skeletal muscles
somatic motor neurons from the CNS, The Neuromuscular Junction
the neuromuscular junction
site where Moto neuron meets the muscle fiber, separated by gap called the neuromuscular cleft
acetylcholine is released from the motor neuron, stimulates the muscle fiber by causing an action potential that moves across that fiber
neural stimulation: muscle twitch
contraction as the result of a single stimulus
neural stimulation: summation
repeated, frequent impulses that lead to an increase in tension
neural stimulation: tetanus
a high frequency of stimulation that leads to a sustained contraction
structures of skeletal muscle: myo- or sarc-
muscle
myocyte
muscle cell, muscle fiber
sarcolemma
muscle cell membrane
sarcoplasm
muscle cell cytoplasm
connective tissues
very strong supporting tissues.
ligaments connect bone to bone to provide skeletal support, tendons connect muscle to bone to transfer the force production from muscle cells to bone
myofilaments
structural proteins in muscle fibers that cause shortening
actin
(thin filament) double helix, has a binding site for calcium
myosin
(thick filament) has arm-like cross-bridges that form strong bonds with actin when calcium binds to actin
sarcomere
functional subunit within a myocyte, z-line to z-line: membrane that separates sarcomeres and is attached to the actin filaments
force regulation in muscle
nature of the motor units neural stimulation, increased frequency of stimulation will sum to reach the threshold of more and faster fibers
more motor units
greater force
faster/larger motor units
greater force
fiber types and performance
Nonathletes
-Have approximately 50% slow and 50% fast fibers
Power athletes
-Sprinters
-Higher percentage of fast fibers
Endurance athletes
-Distance runners
-Higher percentage of slow fibers
Fiber type is not the only variable that determines success in an athletic event
endurance training
greatest adaptation in SO fibers, can result in shift in characteristics of FOG and FG fibers toward more oxidative capacity
resistance training
greatest adaptation in FG and FOG fibers, can result in shift in characteristics of SO and FOG fibers
heart
pumps blood and creates pressure in the vascular system
arteries and arterioles
vessels that carry blood away from the heart
capillaries
vessels that allow for the exchange of nutrients/gasses with tissues
venules and veins
vessels that carry block back toward the heart
blood
plasma, hematocrit
hematocrit
primarily red blood cells, white blood cells, platelets. hematocrit explains why blood is actually thicker than water
main functions of the cardiovascular system
transport O2 and nutrients to tissues, removal of CO2 and removal of metabolic by-products, regulation of body temperature
systemic circuit
left side of the heart, pumps oxygen-rich blood to the whole body via arteries, returns oxygen-poor blood to the right side of the heart via veins
pulmonary circuit
right side of the heart, pumps oxygen-poor blood to the lungs via pulmonary arteries, returns oxygen-rich blood to the left side of the heart via pulmonary veins
cardiac output (Q)
total amount of blood ejected from the heart per min (L/min), product of heart rate and stroke volume
Q = HR x SV
arterial blood pressure
systolic/diastolic
systolic pressure
top number, pressure generated in aorta/arteries due to the heart's ventricular contraction (systole)
diastolic pressure
button number, pressure in the aorta/arteries during the heart's ventricular relaxation (diastole)
central command theory
initial signal to "drive" cardiovascular system comes from higher brain centers, located in medulla oblongata
decrease in heart rate
parasympathetic nervous system, vagus nerve releases acetylcholine, slows HR by inhibiting SA and AV nodes
increase in HR
sympathetic nervous system, increases HR by stimulating SA and AV nodes, uses norepinephrine at beta receptors in heart
factors affecting heart rate at rest
age, biological sex, posture, ingestion of food, emotion, body temperature
end-diastolic volume (EDV)
Volume of blood in the ventricles at the end of diastole , like filling a water balloon with more and more water
regulation of venous return
venoconstriction: reducing the volume of the veins
skeletal muscle pump: rhythmic skeletal muscle contractions force blood in the extremities toward the heart
respiratory pump: increased rate and depth of breathing promotes blood flow toward the heart
total peripheral resistance (aortic blood pressure)
pressure that the heart must pump against to eject blood into the systemic circuit
strength of ventricular contraction
"contractility"; increased contractility results in higher stroke volume; circulating epinephrine and norepinephrine cause a direct sympathetic stimulation of the heart
factors affecting stroke volume at rest
posture/gravity, size of heart, non-pathologic cardiac hypertrophy, pathologic cardiac hypertrophy
non-pathologic cardiac hypertrophy
an exercise-induced increase in the thickness of the heart walls, with an increase in the chamber size
pathologic cardiac hypertrophy
a disease-induced increase in the thickness of the heart walls, with a decrease in the chamber size
Q versus VO2 at max
cardiac output (Q) during maximal exercise can increase 4-8 times
oxygen consumption (VO2) can increase 10 to 20 times at max