PNS PALM 750

this neuropathy displays wallerian degeneration, myelin ovoids when axons fragment and typically keeps the same conduction velocity

axonal neuropathy

this pseudo tumor is formed when outgrowing neurons fail to find their distal target

traumatic neuroma

this condition occurs when Schwann cells and their myelin sheaths are damaged creating a nerve with slower conduction velocity

demyelinating neuropathy

this condition is irreversible, can be due to infections and toxins, affects proximal and distal parts of the body and damages neurons

neuronopathies

carpal tunnel and bells palsy are an example of what

mononeuropathy

diabetes causes distal and proximal ascending symmetric neuropathy of multiple nerves in this condition

polyneuropathy

vasculitis is a common cause of this disease which affects individual nerves in a haphazard fashion

mononeuritis multiplex

autoimmune diseases like chronic inflammatory demyelinating polyradiculopathy cause this condition where there are symmetric symptoms involving proximal and distal body with nerve roots as well as peripheral nerves being affected

polyradiculoneuropathy

this condition displays ascending paralysis, arreflexia, , is caused by an autoimmune response triggered by a microbe, displays segmental demyelination and demyelination affecting the axons and injures the myelin sheath via macrophages?

Guillain barre syndrome

this disease is characterized by symmetrical mixed sensorimotor polyneuropathy persisting for 8 weeks or more and responds well to steroids!!!

chronic inflammatory demyelinating polyradiculoneuropathyi

in CIDP, what can be seen on sural nerve biopsies?

evidence of recurrent demyelination and remyelination associated with Schwann cell proliferation and potential onion bulbing of Schwann cells

which form of leprosy is seen as segmental demyelination and demyelination that progresses to axonal degeneration, most severe in distal extremities and face and involves small pain fibers predisposing to chronic ulcers?

lepromatous

which form of leprosy is associated with a cell mediated response to M leprae causing dermal nodules with granulomatous inflammation which injures underlying nerves?

tuberculoid

this condition is associated with prominent bulbar and respiratory muscle dysfunction due to peripheral nerve dysfunction from an exotoxin. it forms membrane in throat!

diphtheriae

this virus lays dormant in sensory ganglia, causes shingles, affects thoracic and trigeminal dermatomes and displays degeneration of axons

varicella zoster

what is the most common pattern of diabetic peripheral neuropathy?

ascending distal symmetric sensorimotor polyneuropathy

how does uremic neuropathy present?

distal symmetric neuropathy with axonal degeneration and regeneration after dialysis

what is the most common form of neuropathy associated with paraneoplastic syndrome?

sensorimotor neuronopathy, usually associated with small cell lung cancer by CD8+ T cells

this inherited peripheral neuropathy is characterized by distal muscle atrophy, sensory loss, foot deformities, demyelinating forms associated with onion bulging

Charcot marie tooth disease

this autoimmune disease is associated with thymomas, auto against each receptors, ptosis, diplopia, and is dx by autoantibodies and decreased muscle response with stimulation

myasthenia gravis

this disease is characterized by antibodies inhibiting Ca channel which blocks each release, increased muscle response with stimulation and sometimes associated with small cell lung carcinoma

Lambert eaton myasthenic syndrome

this myopathy is associated with telangiectasis, proximal muscle weakness, skin changes like heliotrope rash and gottron papules, and perifascicular atrophy with inflammatory cell aggregates

dermatomyositis

this myopathy is most severe in quads and distal upper extremities, is the most common inflammatory myopathy of older individuals, and characteristically has fatty replacement, rimmed vacuoles and mononuclear infiltrates?

sporadic inclusion body myositis

this syndrome is associated with a complete loss of dystrophin, segmental myofiber degeneration and regeneration, fatty replacement, death at 25-30

Duchenne muscular dystrophy

this dystrophy is associated with partial loss of dystrophin, presents later in childhood, segmental myofiber de and regeneration with fatty replacement, and has a slower course

Becker muscular dystrophy

this dystrophy is associated with decreased cl- channel causing myotonia, sk m weakness, cataracts, endocrinopathy and cardiomyopathy

myotonic dystrophy

myophosphorylase deficiency with muscle damage with exercise is also called

mcardle disease

acid maltase deficiency that is severe in infancy causing generalized glycogenesis is called

pompe disease

what is a common feature of mitochondrial myopathies?

chronic progressive external opthalmoplegia

which neurofibroma most commonly can become MPNST

plexiform neurofibroma

what tumor can MPNST be hard to distinguish from?

undifferentiated sarcoma

this form of MPNST can have rhabdbmyoblastic morphology and is known as what?

triton tumor