GROUP A Beta-Hemolytic Streptococci | Streptococcus pyogenes

M protein

MAJOR VIRULENCE FACTOR

M protein

Prevents phagocytosis due to EMM gene

Streptolysin O

Antigenic / Immunogenic

Streptolysin O

once this is released in our body, it will stimulate our body to produce anti-streptolysin O (ASO)

Streptolysin O

Oxygen labile/sensitive

Streptolysin O

can cause sub-surface hemolysis

ANAEROBICALLY

Streptolysin O - Can cause hemolysis when incubated ___

Streptolysin S

Non-antigenic/Non-immunogenic

Streptolysin S

Oxygen stable

Streptolysin S

Can cause surface hemolysis

AEROBICALLY*

Streptolysin S- Can cause hemolysis when incubated ____

Protein F

Promotes attachment to epithelial cells

Erythrogenic Toxin (Pyrogenic Toxin)

Responsible for rashes in Scarlet Fever

Streptokinase

(Staphylokinase is the counterpart in S.aureus)

• promotes dissolution of clot (clot lysis) or fibrinolysis

Hyaluronidase

(spreading factor- enhances the ability of the organism to invade tissues)

SBA

✔ Media for initial isolation:

-

Catalase Test

(+) beta-hemolysis

SBA

(+) red

LAP Test

(+) red color

PYR Test

SENSITIVE

Bacitracin

(+) erythema

Dick’s Test

(+) Fading of rashes

Schultz Charlton