IPS1 - [Sterile Dosage Forms] - Methods Of Sterilization

Proverbs 16:3

● Steam Sterilization (Autoclaving)

● Dry-Heat Sterilization (Ovens)

● Sterilization by Filtration

● Gas Sterilization

● Sterilization by Ionizing Radiation

Methods of Sterilization

Steam sterilization

[METHODS OF STERILIZATION]

This employs STEAM under pressure in an AUTOCLAVE.

Steam sterilization

[METHODS OF STERILIZATION]

This is applicable to pharmaceutical preparations and materials that can withstand the required temperatures and are penetrated but NOT ADVERSELY affected by MOISTURE.

Steam sterilization

[METHODS OF STERILIZATION]

This uses 121°C at 15 psi for 20 minutes setting.

121°C at 15 psi for 20 minutes

[METHODS OF STERILIZATION]

Steam sterilization uses ___ setting.

Dry-heat sterilization

[METHODS OF STERILIZATION]

This employs CONVECTIVE heat in OVENS.

Dry-heat sterilization

[METHODS OF STERILIZATION]

This is LESS EFFECTIVE than steam sterilization.

Dry-heat sterilization

[METHODS OF STERILIZATION]

This is an effective method for sterilizing GLASSWARE and SURGICAL instruments.

Dry-heat sterilization

[METHODS OF STERILIZATION]

This is the METHOD OF CHOICE when DRY apparatus or dry containers are required, as in the handling of packaging of dry chemicals or NON-aqueous solutions.

Dry-heat sterilization

[METHODS OF STERILIZATION]

This uses 150°C-170°C for 2-4 hours setting.

150°C-170°C for 2-4 hours

[METHODS OF STERILIZATION]

Dry-heat sterilization uses ____ setting.

Sterilization by Filtration

[METHODS OF STERILIZATION]

This is applicable to HEAT-LABILE parenterals.

Sterilization by Filtration

[METHODS OF STERILIZATION]

This involves removal of microorganisms by adsorption on a FILTER MEDIUM or by SIEVING mechanism.

Sterilization by Filtration

[METHODS OF STERILIZATION]

This uses a membrane filter or cellulose ester membrane filter.

● Membrane filter

● Cellulose ester membrane filter.

[METHODS OF STERILIZATION]

Sterilization by Filtration uses a ___ filter

Gas Sterilization

[METHODS OF STERILIZATION]

This is applicable to STERILE POWDERS and PLASTIC CONTAINERS.

Gas Sterilization

[METHODS OF STERILIZATION]

This involves AUTOCLAVING the materials first, then the gases are introduced.

Gas Sterilization

[METHODS OF STERILIZATION]

This is useful in sterilization of MEDICAL and SURGICAL supplies and appliances such as catheters, needles, and plastic disposable syringes.

● Ethylene oxide

● Propylene oxide

[METHODS OF STERILIZATION]

Gases used in GAS STERILIZATION

Sterilization by Ionizing Radiation

[METHODS OF STERILIZATION]

This exposes the material to RADIATION EMITTING ISOTOPES.

● Gamma rays

● Cathode rays

● Beta rays

[METHODS OF STERILIZATION]

Radiation emitting isotopes used in IONIZING radiation