Cellular injury (Ren)

Slide 1-56

1. What is the structure at the bottom?

2. What is the large circular structure at the right?

3. What process is occurring at the right-most area?

1. Intermediate filaments

2. Lysosome

3. Pinocytosis

1. Identify the cellular adaptation

2. What stain is used in this slide?

3. What is the most common cause of this adaptation?

1. Atrophy of muscle fibers

2. Trichrome stain

3. Disuse atrophy

1. Identify the cellular adaptation

2. What causes this particular adaptation?

1. Atrophy of testis

2. Unilateral testicular atrophy is most likely caused by cryptorchidism

1. Identify the cellular adaptation

2. What is the clinical diagnosis?

1. Atrophy of cerebrum

2. Alzheimer disease

1. Identify

2. What causes this cellular adaptation to occur?

3. Identify the pointed structure

4. What cellular process is occurring?

1. Atrophy of centrilobular region of liver

2. Hypoxia

3. Lipochrome

4. Autophagocytosis

1. Identify

1. Hypertrophy of heart

1. Identify

2. What caused this cellular adaptation?

3. What may the patient experience?

1. Hyperplasia of endometrium

2. Continued hormonal stimulation

3. Vaginal bleeding

1. Identify

2. What is the estimated weight of this specimen?

3. What is the pattern of increase?

4. Is this physiologic or pathologic?

1. Hyperplasia of prostate

2. 70 gm

3. Nodular

4. Pathologic

1. Identify

1. Hyperplasia, prostate

1. Identify

2. Identify the pointed structure

1. Squamous metaplasia of larynx

2. Squamous epithelium

1. Identify

2. CD?

1. Metaplasia, gastric columnar mucosa in esophagus

2. GERD

1. Identify

2. What is the pointed structure?

1. Dysplasia, cervix

2. Dysplastic epithelium

1. Identify the type of cell death

2. What cellular process is occurring?

3. What enzymes are involved?

1. Apoptosis, viral hepatitis

2. Apoptosis

3. Caspases

1. Identify the type of cell death

1. Apoptosis, fetal thymus

1. Identify the type of cell death and CD

1. Coagulative necrosis, myocardial infarction

1. Identify the type of cell death and CD

2. What symptom may accompany this pathology?

1. Coagulative necrosis, myocardial infarction

2. Visceral pain

1. Identify the type of cell death and CD

1. Coagulative necrosis, renal infarction

1. Identify the type of cell death and CD

2. What zone is the arrow pointing at?

1. Coagulative necrosis, renal infarction

2. Hemorrhagic zone

1. Identify the type of cell death and CD

2. Why is the area just under the capsule is spared?

1. Coagulative necrosis, adrenal infarction

2. Blood supply from capsular arterial branches

1. Identify the type of cell death and CD

1. Coagulative necrosis, splenic infarctions

1. CD

1. Small intestinal infarction

1. Identify the type of cell death and CD

1. Liquefactive necrosis, lung abscesses

1. Identify the type of cell death and CD

2. What type of exudate is seen grossly?

1. Liquefactive necrosis, liver abscess

2. Purulent exudate

1. Identify what type of cell death and CD

2. What happens to the liquefied area when it resolves?

1. Liquefactive necrosis, cerebral infarction

2. Cystic space

1. What type of cell death and CD

2. What are the cells on the right that cleans up necrotic cellular debris?

1.Liquefactive necrosis, cerebral infarction

2.Macrophage

1.Identify type if cell death and CD

2.What do you call the creamy yellow material commonly seen in this type of necrosis?

3.What is left behind after removal of the dead tissue?

1.Liquefactive necrosis, cerebral infarction

2.Pus

3.Cavity

1.Resolution of a liquefactive necrosis in the brain leads to the development of?

1.Cystic space

1.Identify type of cell death

2.What do you call the grossly visible chalky-white areas seen on the cut surface?

3.Seen in what type of medical emergency?

1.Fat necrosis, pancreas

2.Fat saponification

3.Acute pancreatitis

1.Type of cell death

2.Necrotic fat cells are seen on which side?

3.describe its appearance

1.Fat necrosis, pancreas

2.Right

3.vague cellular outline, lost their peripheral nuclei, cytoplasm is pink amorphous mass of necrotic material

1.type of cell death

2.This type of necrosis is encountered most often in what condition?

1.Caseous necrosis, hilar lymph node

2.Tuberculosis and fungal infection

Caseous necrosis, extensive in lung

Caseous necrosis, lung

Gangrenous necrosis, foot

Gangrenous necrosis, lower extremity

Gangrenous necrosis

Mallory's hyaline, liver

Neurofibrillary tangles, Alzheimer disease

Steatosis, liver

Cirrhosis, liver

Amyloid deposition, Congo red stain

Alpha-1-antitrypsin deficiency with globules in liver, PAS stain

Gaucher disease, spleen

Lipochrome in hepatocytes

Hemosiderin in pulmonary macrophages

Hemosiderosis of liver, iron stain

Hemosiderin deposition in renal tubules, iron stain

Scleral icterus (jaundice) seen in eye

Bilirubin in liver (cholestasis)

Jaundice (icterus) of skin

Anthracotic pigmentation seen on surface of lung

Anthracotic pigment in macrophages of hilar lymph node

Dystrophic calcification, stomach

Metastatic calcification of lung with hypercalcemia