Metronidazole (Flagyl) - Antibiotic for Peptic Ulcer Disease

These flashcards cover key information about Metronidazole, including its therapeutic uses, adverse reactions, contraindications, precautions, client instructions, and drug interactions.

What therapeutic uses does Metronidazole have in its IV form?

• Bacterial infections related to colorectal, abdominal, and vaginal surgeries.

What conditions can oral Metronidazole treat?

• C. diff, bacterial vaginal infections, intestinal and systemic amebiasis, giardiasis, and trichomoniasis in both males and females.

• H. pylori

What are common adverse drug reactions associated with Metronidazole?

• N/V, diarrhea, headache, vertigo, ataxia, seizures,

• Peripheral neuropathy, darkening of urine, anorexia, and dry mouth.

What should be monitored while a patient is on Metronidazole?

• Monitor for and report any severe GI or CNS manifestations.

What are the contraindications for Metronidazole?

• Active CNS diseases and

• Pregnancy (due to teratogenic risk).

What precautions should be considered when administering Metronidazole?

• Use with caution in patients with heart failure, liver or renal failure,

• Seizure disorders, and history of blood disorders.

What are some important client instructions when taking Metronidazole?

• Take just before, with, or after a meal if GI symptoms occur;

• Report severe symptoms;

• Do not be alarmed by urine discoloration;

• May experience metallic taste, headache, dizziness;

• Avoid alcohol.

What reactions can occur when Metronidazole is taken with alcohol?

• A disulfiram-type reaction.

How should sustained-release Metronidazole tablets be taken?

• They must be swallowed whole and should not be crushed or chewed.

What interactions can increase or decrease the effects of Metronidazole?

• Alcohol can cause disulfiram (a hangover-like reaction), while phenobarbital decreases blood levels of Metronidazole, and it can increase lithium levels.