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contract
all muscles have the ability to
stimulated
all muscles must be ____ to move
Skeletal
type of muscle that is striated and controls voluntary movement
Cardiac
type of muscle that is striated and controls involuntary movement
Smooth
type of muscle that is innervated by the autonomic nervous system and controls involuntary movement
allow locomotion and movement of limbs
primary role of skeletal muscle
circulation, digestion, respiration, reproduction, waste removal
some of the physiological processes that smooth muscle does predominantly
skeletal muscle
makes up the meat of livestock animals; voluntarily contracts to allow movement of bones; nearly all are connected to bones using tendons
Flexor
muscle on the side of the limb toward which a joint bends; decreases angle between the segements
Extensor
the muscle on the side of the limb opposite toward where it bends; increases the angle between segments
Adductors
muscles that pull a limb toward the median plane
Abductors
muscles that move the limb away from the median plane
Sphincters
muscles that surround an opening; can be striated or smooth
Cutaneous muscles
occur in superficial fascia between skin and deep fascia covering skeletal muscles; allows movement of skin
Epimysium
connective tissue covering entire muscle
Perimysium
connective tissue layer that covers bundles of muscle
hundreds of muscle bundles
each muscle is made up of _______
thousands of muscle fibers
each muscle bundle is made up of ________
Sarcolemma
Membrane surrounding the muscle fiber; excitable membrane with electrical potential
Sarcoplasm
the cytoplasm of muscle
Sarcoplasm reticulum
specialized form of endoplasmic reticulum that lies within each muscle fiber; just under the sarcolemma; composed of longitudinal tubules that parallel the muscle fiber that terminate in flattened channels called terminal cisternae
Sarcomere
repeating units within muscle fibers; each muscle fiber is made up of approximately 20,000 repeating units; basic contractile unit of skeletal muscle; made up of thick and thin filaments
Z lines, thin filament
sarcomeres are separated by ____, and _____ _____ attach to them
I bands
contain only thin filaments
A bands
contain both thick and thin filaments
H zone
contains only thick filaments
shorten, Z lines
during contractions, sarcomeres ____ and ___ ____ are pulled closer together
Myofilaments, I bands, H zone
_____ DO NOT change length, __ ____ shorten as myofilaments slide over each other, __ ____ disappears
actin
thin filaments are made up primarily of
two strands of actin proteins
each actin filament is composed of
tropomyosin
what is wrapped around the two actin strands in thin filaments
troponin complex
a third protein in the thin filament made up of T, C, and I types
myosin
thick filaments are composed of
thick helical rod with globular head
what a thick filament looks like
swivel at helical rod and globular head, hinge in helical rod
two flexible regions of thick filaments
ordered tail-to-tail interactions
myosin filament is formed by
high affinity for binding actin, ATP and catalyze its conversion to ADP + P
globular heads of myosin have __________ and also bind ________
Myosin heads activated by ATP, heads attach to actin and pull, ADP is released, thin filaments slide past thick filaments, ATP binds to myosin head and detaches it from actin
steps of contraction when ATP is available and Ca+ level near the troponin-tropomyosin complex is high
six
each thick filament is surrounded by ___ thin filaments
three
each thin filament is in contact with ____ thick filaments
actin and myosin are in close proximity but are not bound, myosin head is bound to ADP + P
at rest, thick and thin filaments
somatic nervous system
nerve fibers that stimulate skeletal muscle generally originate in
alpha motor neurons
large, myelinated fibers which branch several hundred times
single muscle cell
each nerve ending stimulates a
single alpha neuron, hundreds
a ____ _____ _____ can stimulate ______ of muscle cells
motor unit
the nerve fiber and muscle cells the nerve ending stimulates
motor end plate
where nerve fibers terminate
synaptic troughs
invaginations on sarcolemmas that increase the surface area
acetylcholine, synaptic cleft, receptors, muscle membranes
action potential travels down the alpha motor neuron and ends up at the motor end plate, resulting in the release of _____ into the _____ ____, then acetylcholine binds to _____ in the _____ _____ to start an action potential in the muscle cell
curare
skeletal muscle relaxant used for anesthesia, acetylcholin antagonist
botulinum toxin
causes paralysis, acetylcholin antagonist
nicotine
affects mood and other hormones, agonist
acetylcholinesterase, acetylcholine, laryngeal spasm
many drugs inactivate _______, which allows the buildup of _______, and smothers people due to ______ ______
sarcolemma, t-tubule, terminal cisternae, longitudinal tubule
where the action potential travels, in order
Ca+ channel
action potential causes the opening of _________ and allows them to rapidly flow into the cell
troponin complex binds up actin filament and uncovers the myosin binding sites on actin
what happens when Ca+ enters the cells from the SR
myosin head binds to actin, releases ADP + P, rotation of myosin
once Ca+ is bound to troponin complex, the __________, _________, and causes a free energy change that results in _____________
power stroke
rotation of the myosin head that pulls the actin towards the center of the sarcomere
4-5 nm
each rotation of the myosin head pulls the actin filaments about
loses affinity for actin, hydrolyzed to ADP + P, resting state
myosin head binds to ATP and _________, ATP is rapidly ________, myosin returns to 90 degree angle and results in __________
stop contraction, elongate the muscle
two steps to relaxation
myosin head binds almost irreversibly with actin
without ATP, this happens in myofilaments
Ca+ pump removes Ca+ from cell
what allows the myosin binding site on actin to be re-covered by troponin/tropomyosin complex
zero
the rate of contraction when the load equals the force of contraction
muscle tone
skeletal muscles always being in a slight state of tension is known as
number of motor units stimulated
the nervous system can adjust the
Isometric contraction
muscle contracts against a load but does not shorten, force of contraction equals force of the load on the muscle, used in posture or types of resistance to a load where movement doesn’t occur
Isotonic contraction
muscle shortens as it contracts, force of contraction is greater than the force of the load, type of muscle contraction involved in movement