2. IRAC Group <--> Mode of Action
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16 Terms
IRAC Group 1A
Inhibits acetylcholinesterase (AChE), causing continuous nerve stimulation.
IRAC Group 1B
Inhibits acetylcholinesterase (AChE), causing continuous nerve stimulation.
IRAC Group 2B
Blocks GABA-gated chloride channels, causing uncontrolled nerve activity.
IRAC Group 3A
Holds voltage-gated sodium channels open, causing continuous nerve firing.
IRAC Group 4A
Activates nicotinic acetylcholine receptors (nAChRs), causing continuous nerve stimulation.
IRAC Group 5
Allosterically activates nicotinic acetylcholine receptors (nAChRs), causing continuous nerve stimulation.
IRAC Group 6
Activates glutamate-gated chloride channels, switching nerve activity off.
IRAC Group 7A
Mimics juvenile hormone, preventing immature insects from developing into adults.
IRAC Group 7B
Mimics juvenile hormone, preventing immature insects from developing into adults.
IRAC Group 7C
Mimics juvenile hormone, preventing immature insects from developing into adults.
IRAC Group 13
Uncouples oxidative phosphorylation, stopping ATP (energy) production.
IRAC Group 15
Inhibits chitin synthesis, preventing formation of a new exoskeleton during moulting.
IRAC Group 20A
Inhibits mitochondrial electron transport (Complex III), stopping ATP (energy) production.
IRAC Group 22A
Blocks voltage-dependent sodium channels, preventing nerve impulses.
IRAC Group 28
Activates ryanodine receptors, causing uncontrolled calcium release and continuous muscle contraction.
IRAC Group 30
Allosterically modulates GABA-gated chloride channels, leading to muscle paralysis