NUR236 topic 7

At the end of this session students should: (4) 

• Have a basic understanding of medications used in psychiatry 

• Understand some of the side effects associated with psychotropic medications 

• Identify appropriate groups of drugs that might be commonly used for common conditions. 

• Practice giving a “depot injection 

 

What are the 5 major classes of psychotropic medications 

• Anxiolytics/Sleepers 

• Anti-depressants 

• Antipsychotics 

• Mood Stabilizers 

• Stimulants 

Discuss Anxiolytics 

• Anti-anxiety agents: Benzodiazepines 

  • Diazepam 

  • Clonazepam 

  • Lorazepam 

  • Nitrazepam 

Benzos all have a different “half-life” influencing the speed, period and intensity of action required 

• Sleepers or Hypnotics (3) 

  • Zolpidem 

  • Zimovane 

  • Melatonin etc 

Discuss about Benzodiazepines: Mechanism of action and indications (7) 

• Enhance the effects  of gamma-aminobutyric (GABA) on the receptor sites 

•     Used in all major anxiety conditions 

•     Sedation in cases of agitation (often PRN) 

•     Alcohol withdrawal syndrome 

•     Sleep disturbance 

•    Anti-convulsant 

• Muscle relaxant 

What are the major side effects of Benzodiazepines (8) 

• Drowsiness, light-headedness and confusion 

•  Unsteadiness (especially in older people, who may have falls and injure themselves as a result) 

•  Dizziness and blurred vision. 

• Slurred speech 

• Muscle weakness 

• Memory problems 

• Constipation 

• Nausea and dry mouth 

What are the other issues of Benzodiazepines 

• Prescribing is restricted in many countries because of potential for tolerance, addiction. 

• For this reason Benzos are rarely prescribed long term, however their short term use in acute psychiatry is common. 

• Severe physical withdrawal syndrome. 

Discuss anti-depressants 

• Anti-depressants are the most commonly prescribed psychotropic medication 

• Commonly prescribed by GP’s in primary care 

• Recommended for mild-moderate depression in conjunction with evidence based psychological therapies 

Anti-depressants: Discuss Selective Serotonin Re-uptake Inhibitors  

• Work very specifically to prevent the re-uptake of serotonin to maximize it’s potential in the synapse 

• SSRI’s are very specific, there are few side effects, much less associated with addiction and tolerance than first generation anti-depressants 

• Used to treat all forms of depression 

• Some are licensed for use in certain anxiety disorders. 

Discuss other Anti-depressants (3) 

• Selective Noradrenaline Re-uptake Inhibitors 

  • Work very similarly to SSRI’s but targeting the re-uptake of noradrenaline  

  • This has been found to be particularly useful in depression complicated by anxiety conditions. 

• Monoamine Oxidase Inhibitors (Monoamine MAOIs).  

Withdrawn in many countries because of dietary contra-indications and side effects with tyramine. 

• Tricyclics: First generation anti-depressants.  

• Less specific in action and often sedating. Generally a wider side-effect spectrum and association with addiction and tolerance. 

Discuss the common side effects of anti-depressants (8) 

• Agitation and anxiety  

• Nausea 

• Indigestion, diarrhoea or constipation 

• Loss of appetite, weight loss/gain 

• Dizziness & blurred vision 

• Dry mouth 

• Excessive sweating 

• Issues with libido 

Discuss anti-psychotics 

• There are two types of anti-psychotics that you will come across working in acute mental health environments. 

• “Typical” antipsychotics: First generation 

• “A-typical” antipsychotics: Second generation 

Discuss typical anti-psychotics 

• receptors in the brain as per the “dopamine hypothesis”. Very simply, if dopamine receptors are blocked, dopamine can’t sit on and stimulate the receptor sites.  

• However they're very unspecific in their selection, blocking lots of other receptors and causing severe side effects. 

• Used for: 

• Acute psychotic episodes (all types) 

• Schizophrenia 

• Acute agitation and arousal 

Discuss the side effects of antipsychotics 

• Typical Antipsychotics cause extrapyramidal side effects (EPSE) 

• These can cause movement and muscle disorders which can be extremely distressing for the patient, often manifesting in symptoms similar to Parkinson's disease. 

• Long term use can cause Tardive Dyskenesia, a movement disorder affecting face, neck and trunk of the body 

Discuss other common side-effects of antipsychotics (5) 

• Dry mouth 

• -Constipation 

• -Photosensitivy 

• -Blurred vision 

• Most side effects, including EPSE can now be treated with other medications with anti cholinergic properties (Benztropine). 

Discuss A-typical anti-psychotics (8) 

• Second generation antipsychotics are know as a-typical. 

• Their action is similar to typical psychotics but more specific to dopamine 2 receptors (a subset of receptors most involved with psychotic symptoms) and also act on serotonin, which is associated with mood and logical thinking. 

• This improves the adverse side effect profile 

• The first a-typical developed was Clozapine.  

• Clozapine has the most complex, but effective binding properties of any other anti-psychotic drug. 

• Unfortunately in 1% of users, it can also cause agranulocytosis, which if not detected early can compromise the immune system and lead to death. 

• For this reason, regular monitoring of neutrophil and lymphocytes is performed, and extra consideration is given when commencing the drug. 

• Clozapine is often effectively used when a person is unresponsive to any other medication. 

No other a-typical anti-psychotics cause agranulocytosis, however they do still cause significant side-effects including: 

• Weight gain 

• Insulin dysregulation 

• Loss of libido and sexual functioning 

However, they are usually tolerated much better than the their first generation cousins, and extensively used in the contemporary management of schizophrenia and psychosis.  

Discuss anti-psychotic depot injection 

• A depot injection is a slow-release form of antipsychotic medication. 

• Originally developed for slow release of typicals in an oil based solution. 

• Both Typical and A typical available as depot injections 

• Given as a deep intramuscular injection 

• Lasts for 2-4 weeks, commonly administered fortnightly 

Discuss Mood Stabilizers 

Mood stabilizers are used to treat affective disorders such as BPAD, and mania. 

Lithium 

• Lithium is a naturally occurring salt and is extremely effective in treating BPAD. 

• The mechanism of action is not entirely understood, however Lithium is thought to act on serotonin and dopamine transmitters 

• Lithium has a very narrow therapeutic range, therefore regular monitoring of serum levels is required. 

• Toxicity can be life threatening, affecting CNS and commonly renal systems. 

Anti-convulsants 

• About 20 years ago, it was discovered that the use of anticonvulsants in high doses was also effective in the treatment of affective disorders. 

• Sodium-Valporate, Carbamazapine and Lamotrigine are now becoming mainstream. 

• Although still requiring monitoring of serum levels, these medications are less “toxic” and cause fewer side effects. 

Discuss stimulants 

• Because of the potential for addiction and abuse, stimulants are rarely used in mainstream psychiatry. 

• However amphetamines are still prescribed for narcolepsy in specialist settings 

• And amphetamine based medications such as Ritalin are used extensively in child and adolescent services for attention deficit disorders 

 

Discuss the Mechanism of Action & common side effects. 

• Amphetamines inhibit the re-uptake of dopamine by effectively holding dopamine onto the receptor sites, stimulating them. 

• Increased stimulation of dopamine receptors at moderate levels is known to help with concentration and focus – hence the usefulness of Ritalin in attention deficit disorders. 

• Common side effects include: Nervousness, trouble sleeping, loss of appetite, weight loss, dizziness, nausea, vomiting, or headache 

 

 5 main groups of psychiatric medications. 

Anxiolytics 

Anti-depressants 

Antipsychotics 

Mood Stabilizers 

Stimulants 

• Basic mechanism of actions 

• Indications 

• Common side effects 

• Delivery of the depot injection. 

Intramuscular Injection sites