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target organs of calcium homeostasis?
intestines
kidney
bone
hypercalcemia ddx?
neoplasia
addisons
parathyroid disease
renal disease
remember GOSH DARNIT
biologically active form of calcium
ionized
PTH ? in response to low calcium, and ? in response to high calcium
increases
decreases
PTH stimulates the kidneys to produce ? which increases the amount of ionized calcium in the body
calcitriol
condition described as a functional mass producing parathyroid hormone
primary hyperparathyroidism
90% of masses that cause primary hyperparathyroidism are
adenomas
Clinical signs of primary hyperparathyroidism?
PU/PD
Decreased appetite
Lethargic
Asymptomatic
Possibly uroliths (CaOx)
primary hyperparathyroidism is generally a disease of ? dogs/cats
older
Expected iCa and PTH with primary hyperparathyroidism?
High iCa
Normal to high PTH
is PTHrP typically positive with primary hyperparathyroidism, neoplasia, or renal disease related hypercalcemia?
neoplasia
most reliable diagnostic tool to assess parathyroid glands for a mass?
cervical ultrasound
cervical ultrasound finding indicative of hyperplastic or neoplastic primary hyperparathyroidism?
hypoechoic structure >4mm
normal parathyroid gland size?
2-3mm
TF the number/location of parathyroid glands can vary between individuals
T
cranially located parathyroid gland that is unassociated with thyroid lobes
external parathyroid gland
caudal pole thyroid lobe embedded in thyroid tissue
internal parathyroid gland
primary hyperparathyroid tx?
Surgery
Heat ablation
Chemical ablation
primary hyperparathyroid tx with the highest cure rate?
surgery
rapid way to improve cure rates during primary hyperparathyroid surgery?
intraoperative PTH concentration assay
complication associated with primary hyperparathyroid tx (surgery, chemical/heat ablation) that results in multiple surgeries, higher morbidity, and increased cost?
persistent hypercalcemia
why can persistent hypercalcemia occur with attempted primary hyperparathyroid treatments?
missed adenoma or hyperplasia
ectopic parathyroid
most common complication associated with all possible treatments of primary hyperparathryoidism?
hypocalcemia
clinical signs of hypocalcemia following primary hyperparathyroid tx?
pawing at face
tremors
muscle fasciculation
mentation change
seizure
death
hypocalocemia may occur within ? of parathyroid surgery
12 hours to 7 days
goal of post-operative management for parathyroidectomy patients?
maintain normocalcemia
emergency treatment of hypocalcemia in post-op parathyroid surgery pts?
calcium gluconate 10% solution 0.5-1.5ml/kg IV slowly
ways to manage non-emergent decreases in iCa with post-op parathyroid surgery patients?
Calcitriol
Calcium carbonate
most common endocrine cancer in dogs
thyroid neoplasia
canine thyroid neoplasia is benign or malignant 90% of the time?
malignant
is canine thyroid neoplasia usually functional or non-functional?
non-functional
clinical signs of canine thyroid neoplasia?
Usually asymptomatic as mostly non-functional
Palpable mass on PE
TF biopsy is a first line diagnostic tool for canine thyroid cancer
F
FNA preferred as highly vascular
thyroid imaging modality of choice to evaluate mobility, invasion, vascularity, and metastasis?
CT
treatment of choice for mobile and non-invasive canine thyroid neoplasia with no distal metastasis?
surgery
recommended treatment for fixed/invasive canine thyroid neoplasia with no distal metastasis?
radiation or I-131 +/- surgery
recommended treatment for canine thyroid neoplasia with distant metastasis?
Palliative care
Radiation
Chemo
I-131
Surgery
if bilateral canine thyroid tumors are surgically removed, there is a risk of post operative ____________
hypoparathyroidism
complications of canine thyroid neoplasia surgical removal?
hemorrhage
laryngeal paralysis
dysphagia
canine thyroid neoplasia treatment modalities other than surgery?
RT
I-131
Chemo
NSAIDs
is feline thyroid neoplasia usually functional or non-functional?
functional
is feline thyroid neoplasia usually benign or malignant?
benign
most feline thyroid tumors are unilateral or bilateral?
bilateral
Pre-operative workup prior to treatment for cats with thyroid tumors?
Screen and treat for HCM
Screen for renal disease
Nuclear scintigraphy
when is surgery indicated for feline thyroid tumors?
Medical managment failed
Suspect carcinoma
what parameters should be monitored following feline thyroid tumor treatment?
Ca
T4
Renal values
Diagnostics for suspect salivary gland disease?
Sedated oral exam
MDB
FNA
CT
salivary gland neoplasia is most commonly seen in what individuals?
Old dogs
Siamese male cats
salivary gland neoplasia biological behavior?
Usually malignant
Locally invasive
High rates of metastasis
clinical signs of salivary gland neoplasia?
Firm swelling
Halitosis
Exophthalmos
Dysphagia
salivary gland neoplasia tx options?
Surgery
RT
limbic epileptic condition of the salivary gland that responds to phenobarbital
sialadenitis/sialadenosis
accumulation of saliva due to a damaged duct within a salivary gland due to trauma, sialolithaisis, foreign body, neoplasia, heartworm disease, or idiopathic causes
salivary mucocele
TF salivary mucoceles are cysts
F
salivary mucocele ddx?
abscess
neoplasia
enlarged lymph node
draining duct
lipoma
what salivary gland is most commonly affected by salivary mucoceles?
sublingual salivary gland
salivary mucocele tx?
sialoadenectomy or marsupializaation
landmarks for incision with a sialoadenectomy?
bifurcation of jugular v. to ramus of mandible
sialoadenectomies require ? dissection
intracapsular
rostral end point in a sialoadenectomy?
lingual nerve
sialoadenectomy steps?
Lateral or dorsal approach
Identify bifurcation of jugular v. and ramus of mandible
Open capsule
Dissect out mucocele down to lingual n.
Drain mucocele
what salivary mucoceles can be treated with sialoadenectomy?
mandibular
sublingual
what salivary mucoceles can be treated with marsupialization?
sublingual
pharyngeal
salivary gland surgery complications?
LN removal
Operate on wrong side
Infection
Recurrence due to wrong side
Recurrence due to incomplete removal
Seroma
Lingual n. damage
indications for esophagostomy tube?
Malnutrition
Hyporexia
Dysphagia
Bypass oral cavity
requirements for esophagostomy tube?
Functional GI tract
Normal esophageal function
Minimal vomiting
No cervical disease
steps for esophagostomy tube placement?
Place pt under GA
Surgically prep left side of the neck
Identify wing of atlas and jugular vein
Place curved hemostats into esophagus via oral cavity and press against the left wall of the esophagus
Make a small incision over the tips of the curved hemostats
Size esophagostomy tube
Grab esophagostomy tube with hemostats and pull back through the mouth
Bend esophagostomy tube on itself and reintroduce it back into the mouth while pulling on opposite end until you feel it flip
Check placement with negative pressure and radiographs
Suture in place with finger trap and cute little collar
where should a correctly placed esophagostomy tube end on radiographs?
before the lower esophageal sphincter
care instructions for esophagostomy tube?
Calculate RER and water needs
Blend food
May medicate via tube
Always flush
Ostomy care with dilute chlorhexidine/saline