PSL 310 Unit 1: Cell Signaling

What are the types of cell signaling?

Juxtacrine, paracrine, autocrine, endocrine, neurocrine, neuroendocrine

Juxtacrine

Cell-cell communication via direct physical attachment to one another

Direct juxtacrine signaling

Two cells directly come into contact through the proteins on their membranes

Gap junction juxtacrine signaling

Hydrophilic channels exchange cytoplasm and ions

Gap junction communication

Cells touch, hydrophilic channel exchanges cytoplasm and ions

Paracrine

Local communication by means of paracrine factors, communication through ligands to cells close to each other

Autocrine

Communication from one cell to the same cell

Process of autocrine signaling

Cell releases ligand, ligand binds to receptor on same cell

Endocrine

Communication from two cells far away, where signaling molecule is released through the bloodstream, more long and global

Neurocrine

Nerve communication, neuron to effector

Neuroendocrine

Endocrine hormones into bloodstream, neurosecretory