Intermediate Filaments and Cytoskeleton

Flashcards covering key concepts related to intermediate filaments, their structure, types, functions, and associated disorders.

Intermediate Filaments (IF)

Cytoskeletal components that provide structural stability and rigidity to cells.

Keratins

Type I & II intermediate filaments primarily expressed in epithelial cells, composed of one acidic and one basic monomer.

Desmin

Type III intermediate filament important for structural integrity in muscle cells.

Neurofilaments

Type IV intermediate filaments that stabilize and link structures in nervous tissue.

Lamins

Type V intermediate filaments found in nearly all cells, forming the nuclear lamina and playing a role in cell structure.

Epidermolysis bullosa simplex

A genetic disorder caused by dysfunction in keratin-5 or keratin-14, leading to fragile skin.

Vimentin

A Type III intermediate filament that may have minimal role in determining the number of lobes in neutrophil nuclei.

Autosomal Dominant Leukodystrophy (ADLD)

A rare genetic condition caused by overexpression of Lamin B1.

Structural integrity

The ability of cells to maintain their shape and resist deformation, often supported by intermediate filaments.

Cytoskeleton functions

Supports cell structure, provides mechanical resistance, and facilitates cellular processes.