Generic Drugs & Efficacy & Toxicity Quiz 1

Amlodipine

Efficacy: Decreased BP, reduction in chest pain, decreased angina attacks

Toxicity: Peripheral edema, HR, LFTs

Atenolol

Efficacy: Decreased BP, chest pain, angina attacks

Toxicity: HR, renal function, HF symptoms

Benazepril

Efficacy: Decreased BP, improved kidney/heart outcomes

Toxicity: K+, SCr, BUN, angioedema

Bismuth subsalicylate

Efficacy: ↓ diarrhea/GI symptoms

Toxicity: Salicylate toxicity, bleeding, dehydration

Bisoprolol

Efficacy: Decreased BP, decreased angina, normalized HR

Toxicity: HR, ECG, renal function

Calcium carbonate

Efficacy: ↓ heartburn/indigestion; adequate calcium

Toxicity: Serum calcium, constipation, renal function

Candesartan

Efficacy: Decreased BP, improved heart failure

Toxicity: K+, SCr, BUN, hypotension

Captopril

Efficacy: ↓ BP, improved HF/kidney function

Toxicity: K+, SCr/BUN, BP, angioedema

Carvedilol

Efficacy: Decreased BP/HR, decreased angina, improved HF

Toxicity: HR, ECG, renal function

Chlorthalidone

Efficacy: Decreased BP/edema, increased urine output

Toxicity: Electrolytes, uric acid, renal/hepatic function

Cimetidine

Efficacy: ↓ heartburn/GI symptoms, ulcer healing

Toxicity: Renal function, mental status, CBC

Clonidine

Efficacy: ↓ BP, improved ADHD symptoms

Toxicity: BP, HR, rebound HTN

Dexlansoprazole

Efficacy: Resolution of GI discomfort

Toxicity: B12, C. difficile with long-term use

Diltiazem

Efficacy: ↓ BP/angina, rate control

Toxicity: HR, HF symptoms, liver toxicity

Enalapril

Efficacy: ↓ BP, improved HF

Toxicity: K+, SCr, BUN, angioedema

Esomeprazole

Efficacy: Resolution of GI symptoms/ulcers

Toxicity: Mg, Ca, bone density

Famotidine

Efficacy: Resolution of GI discomfort

Toxicity: Renal function, CBC

Felodipine

Efficacy: ↓ BP, ↓ angina

Toxicity: Edema, HR, liver function

Fosinopril

Efficacy: ↓ BP, improved HF

Toxicity: K+, SCr, BUN, angioedema

Hydrochlorothiazide

Efficacy: ↓ BP/edema

Toxicity: Electrolytes, renal function, uric acid, glucose

Irbesartan

Efficacy: ↓ BP, ↓ urine protein

Toxicity: K+, renal function

Labetalol

Efficacy: ↓ BP/HR

Toxicity: Liver function, glucose, bronchospasm

Lansoprazole

Efficacy: Resolution of GI symptoms/ulcers

Toxicity: Mg, SCr, LFTs, bone loss

Lisinopril

Efficacy: ↓ BP, improved HF/kidney disease

Toxicity: K+, SCr, BUN, angioedema

Losartan

Efficacy: ↓ BP, ↓ urine protein

Toxicity: K+, renal function

Metoprolol

Efficacy: ↓ BP/angina, improved HF

Toxicity: HR, ECG, glucose, renal function

Misoprostol

Efficacy: Prevention/healing of gastric ulcers

Toxicity: Diarrhea, abdominal pain, uterine bleeding/contractions

Nifedipine

Efficacy: ↓ BP, ↓ chest pain/angina attacks

Toxicity: Edema, tachycardia, HF

Olmesartan

Efficacy: ↓ BP, ↓ urine protein

Toxicity: K+, SCr, hypotension

Omeprazole

Efficacy: Resolution of GI discomfort/ulcers

Toxicity: Mg, LFTs, bone density

Pantoprazole

Efficacy: Resolution of GI discomfort/ulcers

Toxicity: Mg, bone density

Propranolol

Efficacy: ↓ BP/angina/migraines

Toxicity: HR, BP, bronchospasm, glucose

Quinapril

Efficacy: ↓ BP, improved HF

Toxicity: K+, SCr, BUN, angioedema

Rabeprazole

Efficacy: Resolution of GI discomfort/ulcers

Toxicity: Mg, Ca, SCr, bone density

Ramipril

Efficacy: ↓ BP, improved HF/kidney disease

Toxicity: K+, SCr, BUN, angioedema

Sucralfate

Efficacy: Ulcer healing, ↓ reflux

Toxicity: Blood glucose in diabetes

Terazosin

Efficacy: ↓ BP, improved urinary symptoms

Toxicity: BP, HR, LFTs

Tetracycline

Efficacy: Resolution of infection

Toxicity: Renal/hepatic function, CBC

Valsartan

Efficacy: ↓ BP, improved HF/CKD, ↓ proteinuria

Toxicity: BP, K+, renal function, LFTs

Verapamil

Efficacy: ↓ BP/HR, improved rhythm, ↓ angina

Toxicity: HR, ECG, LFTs, SCr, HF