Antibiotics

Aminoglycosides

Low (<0.3) Vd

-ve

CDD (Concentration)

MOA: Protein synthesis inhibition

Adverse Effects: Nephro- and ototoxicity

Cephalosporins

Medium (0.3–1) Vd

+ve and -ve

TDD (Time)

MOA: Cell wall synthesis interference

Adverse Effects: Anaphylaxis, GI disturbances

Chloramphenicol/florfenicol

High (>1) Vd

+ve and -ve

TDD (Time)

MOA: Protein synthesis inhibition

Adverse Effects: Bone marrow depression, disturbance of RBC maturation in cats, GI disturbances, lethargy

Carbapenems

Low (<0.3) Vd

+ve and -ve

TDD (Time)

MOA: Cell wall synthesis interference

Adverse Effects: GI disturbances, CNS toxicity, infusion reactions

Penicillins

Low (<0.3)

+ve and -ve

TDD (Time)

MOA: Cell wall synthesis interference

Anaphylaxis

Tetracyclines

High (>1)

+ve and -ve

Co-dependent

MOA: Protein synthesis inhibition

Adverse effect: GI disturbances, acute cardiotoxicity, discolouration of teeth

Quinolones / Fluoroquinolones

High (>1)

+ve and -ve

CDD (Concentration)

MOA: DNA replication disturbance

Adverse effect: Cartilage damage in young fast growing animals

Rifampin

High (>1)

+ve and -ve

MOA: DNA-dependent RNA polymerase