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Neurons and glia
What are the two main types of cells in the nervous system?
Gene expression
What defines the type and functions of nervous system cells?
25%
The brain accounts for 2% of body mass but uses what percentage of daily energy?
86 billion
Approximately how many neurons are in the human brain?
Electrical and chemical
What type of signals do neurons use for communication?
Synapses
Where does communication between neurons occur?
Afferent
Which neuron type carries messages towards the brain and is sensory neurons?
Efferent
Which neuron type carries messages away from the brain? and is motor neurons
Interneurons
Which neurons carry messages between other neurons?
Dendrites
Receive signals
Soma
Cell Body
Axon
Transmit signals
Myelin Sheath
Insulating layer
Node of Raniver
Gap between the myelin sheath and lets the electrical signal jump form node to node
Axon Terminal
End of the axon: releases neurotransmitters to send the signal to the next cell
Nerve glue
What does the term 'glia' literally mean?
Glia
Support neuronal signaling, provide nutrients, and guide neurons in development and is non-electrical
30-60%
What percentage of total brain mass is composed of glia?
True
Glial cells are non-electrical.
Astrocytes
Which glial cell maintains the blood-brain barrier, synaptic functions, energy and metabolism and dvelopment?
Microglia
Which glial cells act as the 'immune system' in the brain, eliminate synapses, and provide signaling to other cells?
Oligodendrocytes
Which glial cell myelinates the Central Nervous System (CNS)?
Schwann cells
Which glial cell myelinates the Peripheral Nervous System (PNS)?
Microglia
Glial cells that eliminate synapses are called
Guide neurons
What is a primary function of astrocytes regarding development?
Brain
Spinal cord
What are the two components of the Central Nervous System (CNS)?
Sensory nerves
What are the components of the Peripheral Nervous System (PNS)?
Somatic nervous
Which system carries information to the CNS via sensory nerves?
Sensory Nerves
Carry information to the CNS
Motor Nerves
Carry information from the CNS to the muscles
Sympathetic
Which division of the PNS is responsible for the 'fight or flight' response?
Parasympathetic
Which division of the PNS is responsible for 'rest and digest'?
12
How many pairs of cranial nerves are there?
Vagus nerve
Which cranial nerve is specifically mentioned as innervating the gut?
Neural circuit
What is a group of neurons connected by synapses that process specific information?
1.Sensory neuron
2.Spine interneuron
3.Motor neuron
4.Muscle contraction
Order the components of a simple reflex circuit:
Bilateral symmetry
What term describes the mirror-image nature of the brain hemispheres?
Dura, arachnoid, pia mater
What are the three layers of the meninges?
Dorsal horn
In the spinal cord, which horn contains sensory interneurons?
Ventral horn
In the spinal cord, which horn contains motor neurons?
Dorsal/ventral root
Axons emerge in bundles
Spinal cord
Tracts carry sensory and motor information to/from brain
31
How many pairs of spinal nerves exit between the vertebrae?
Cerebral spinal fluid (CFS)
-Cushions and protects the brain
-Exchanges material between the blood and the brain
Choroid plexus
What tissue makes cerebrospinal fluid (CSF)?
1. Lateral ventricles
3rd ventricle
4th ventricle
Central canal
Order the directional flow of CSF:
Vascular system
-Provides nutrients/energy
-Carries away waste
Gray Matter
-Cell bodies
-Dendrites
White Matter
Myelinated axon
Volts
What unit is used to measure electrical potential across a membrane?
Amps
What unit is used to measure the flow of charge (current)?
Siemens
What unit is used to measure conductance?
-70 mV
What is the typical resting potential of a neuron?
True
At rest, a neuron contains more negative charges than positive charges inside.
It increases
What happens to the membrane potential when a neuron gains positive charges?
It decreases
What happens to the membrane potential when a neuron gains negative charges?
Na+
Cl-
Ca2+
Which ions are high in the extracellular fluid at rest?
K+
Which ion is high in the intracellular fluid at rest?
Ion pumps
What protein machines use ATP to move ions against their gradient?
Ion channels
What protein machines provide selective, passive gateways for ions?
+52 mV
At what membrane potential is the influx of Na+ equally opposed by repulsion?
diffusive force
The force that pushes K+ out of a typical neuron is the
True
Ion pumps and ion channels are both transmembrane and selective.
ATP
What energy source do ion pumps require?
7,000
How many synaptic partners does a typical neuron have?
400
Up to how many messages per second can a neuron send?
Presynaptic terminal
What is the term for the sending side of a synapse?
Postsynaptic terminal
What is the term for the receiving side of a synapse?
Glutamate
GABA
Dopamine
Serotonin
Which of the following are neurotransmitters?
Na+
What does EPSP stand for?
Cl-
Which ion influx typically causes an IPSP?
More likely
What happens to the likelihood of an action potential during an EPSP?
Less likely
What happens to the likelihood of an action potential during an IPSP?
Electrical synapse
What type of synapse allows signals to pass in both directions?
Connexon
What physical bridge connects neurons in an electrical synapse?
Returns to rest
What happens to a neuron if it does not reach threshold?
Spatial summation
The summation of EPSPs from two different synapses is called
Temporal summation
The summation of EPSPs from one synapse over time is called
~1 ms
Approximately how long do EPSPs and IPSPs last?
Threshold
What must be reached for an action potential to be triggered?
Rising phase
In which phase does the membrane potential become positive?
Falling phase
In which phase does the membrane potential switch back to negative?
Undershoot
What is the term for the membrane potential dipping below rest?
Absolute refractory period
What is the period when a neuron cannot fire again?
Voltage-gated Na+ channels
Which channels are critical for the action potential wave?
K+ exit
What drives repolarization during an action potential?
Firing frequency
How is information encoded in action potentials?
True
Motor neurons are spontaneously active.
Fires less frequently
What happens to motor neuron firing when receiving inhibitory input?
Saltatory conduction
What term describes action potentials jumping between nodes of Ranvier?
Increases speed
What is the effect of myelin on conduction speed?
~100
Approximately how many EPSPs are needed to trigger an AP in a cortical neuron?
False
Action potentials can move both forward and backward down an axon.
Hyperpolarization
What resets the voltage-gated Na+ channels?
Nodes of Ranvier
Where are voltage-gated channels most densely packed in myelinated axons?
Gets smaller
What happens to the signal size as graded potentials spread?
Axon hillock
Which location's proximity determines the strength of an EPSP's effect?
Resting potential
Threshold
Rising phase
Falling phase
Undershoot
Order the phases of an action potential:
Medial
Closer to midline
Lateral
Farther from midline