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asthma/COPD + non selective beta blockers (propranolol, carvedilol)
blocks beta2 receptors in airways, bronchospasm
pregnancy + ACE inhibitor, ARBs, statins, warfarin, isotretinoin, tetracyclines
High teratogenic risk
Pediatrics <19 + aspirin
Reye’s syndrome following viral illness
Gout + thiazide diuretics, low-dose aspirin
increase uric acid levels, gout flares
Peptic ulcer disease + NSAID, systemic corticosteroids
inhibits protective stomach prostaglandins, increase risk of GI bleeding and perforation
Heart failure + NSAIDs + TZD (pioglitazone)
fluid retention and worsening heart failure symptoms