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Abrasions
Partial-thickness dermal wounds
Preservation of the dermis
What permits abrasions to heal well by re-epithelialization?
Accelerates epithelialization as opposed to a wound that scabs over
What is the benefit of a moist wound environment?
Lacerations (tissues sharply incised, trauma to the surrounding area is minimal)
Wounds that involve the tearing of skin and deeper tissues
Age of the lesion, size, and the extent of contamination
What does a wound's ability to close depend on?
Lavaged, debrided, and closed primarily
How are fresh lacerations with limited contamination treated?
Degloving injury (bone abrasion, joint exposure, heavy contamination with
foreign debris)
Type of injury that occurs as a large section of skin is torn off the underlying tissue
Aggressive wound lavage and wound debridement before granulation tissue
formation
How are degloving injuries initially treated?
A bandage that holds moisture
What is an occulsive bandage?
Penetrating wounds (bites, bullets, arrows, sticks, antlers, etc.)
Which wound is most commonly seen in veterinary patients?
Due to extensive injury to deeper tissues that may not be apparent on skin inspection
Why are penetrating wounds difficult to assess?
Sealed with sterile gauze and adhesive occlusive film (Ioban-3M)
How are penetrating wounds that involve the thorax and abdomen treated before surgery?
Contaminated
Bite wounds are always considered to be _____
• Surgical exploration, lavage, and debridement.=
• Closure depends on ability to remove contaminated and damaged tissue
• Drains used to move fluid out of dead space
How are penetrated wounds treated?
Severe inflammation and sepsis that can culminate in systemic inflammatory response syndrome (SIRS)
What an result if bites or underlying trauma caused by penetrating wounds are left untreated?
Classified on the base of the depth and the size of the affected area
How are burn injuries classified?
Animals with poor cutaneous blood flow due to hypothermia
Which patients are most at risk of heating pad related burns?
Confined to the outermost layer of skin (epidermis)
What constitutes a first-degree burn?
• Skin is red and painful but re-epithelializes within a few days without treatment
• Often heals by secondary intention
How is a first-degree burn treated?
Full-thickness epidermal and partial-thickness dermal injury
What constitutes a second-degree burn?
• Epidermis can appear yellow-white, black, charred, and may slough and leak
plasma
• Painful or non-painful to the touch
• Hair follicles can be spared or destroyed
How does a second-degree burn appear?
• Full extent of damage may not be known until several days after injury
• If not severe, will heal by epithelialization with minimal scarring in 10-21 days
• Severe burns may require surgical intervention
How is a second-degree burn treated?
Full-thickness injuries of the epidermis and deep-layer dermis, characterized by eschar that is insensitive to touch
What constitutes a third-degree burn?
Eschar
Leathery, black layer of dead tissue that sloughs off healthy skin after injury
• Extensive surgical intervention with eschar removal
• Wound debridement
• Application of skin grafts and flaps if second-intention healing is not possible
• Life-threatening and systemic effects are likely
How is a third-degree burn treated?
Involve tissue extending beyond the dermis, including muscle, tendon, and bone
What constitutes a fourth-degree burn?
• Surgical intervention required to prevent scarring that restricts movement
• Animals are critically ill and require intensive care to survive
• Fish skin grafts can be used when skin grafting is not an option
How is a fourth-degree burn treated?
Skin compression on hard surfaces during extended periods of recumbency
What causes decubitual ulcers over bony prominences?
Lateral or caudal surface of the olecranon
Identify the most common location for decubital ulcers
Pressure necrosis of the skin particularly over the olecranon, the calcaneus, and bony prominences of the feet
What can inappropriate or prolonged periods of bandaging lead to?
Prevention
What is the best treatment for decubital ulcers and bandage-associated pressure sores?
• Reddening of the skin with hair loss as early signs
• White, purple, or black color changes indicate severe damage to the dermis • Severe damage leads to sloughing and an open wound
Identify signs of pressure on the skin
Treated by second intention healing
How are most pressure sores treated?
Infection, dehiscence, or seroma formation
Identify complications that may occur at any time during the wound healing process
Dehiscence
The breakdown of a surgical wound
• Insufficient debridement causing wound edges start to become necrotic
• Poor local blood supply
• Suture reaction
• Movement of wound edges
What causes wound dehiscence?
• Redness and irritation
• Swelling
• Discharge
• Separation of the wound edges
Identify the signs of wound dehiscence
Seroma (usually don't require treatment as the fluid will be reabsorbed gradually over time)
The accumulation of serous fluid under the skin
• Where surgery has involved removal of SQ tissue
• Where skin is particularly loose or mobile creating dead space
Where do seromas typically form?
1 - Inflammatory phase
2 - Proliferative phase
3 - Maturation phase
Identify the phases of wound healing
Inflammatory phase (begins immediately and lasts for 3-5 days)
What is the first phase of wound healing, and how long does it last?
Platelets aggregate and form a fibrin clot within the wound to control bleeding and stabilize the wound edges
What is the role of platelets during the inflammatory phase of wound healing?
Macrophages and neutrophils
Identify two types of white blood cells present in the inflammatory stage that engulf pathogens to help the immune system heal injuries
• Modulate wound healing by releasing more growth factors
• Remove bacteria and cellular debris from the wound
What is the role of macrophages and neutrophils during the inflammatory phase of wound healing?
Formed of white blood cells and body fluid that leaks from blood vessels into nearby tissues
What is wound exudate?
The lag phase because wound strength is at its lowest during this phase
The inflammatory stage is also referred to as
Proliferative phase (Begins at 3-5 days after injury and continues for 2-4 weeks)
What is the second phase of wound healing, and how long does it last?
Proliferative phase
Identify the phase of wound healing marked by fibroblasts and endothelial cells migrating into the wound
A type of cell that contributes to the formation of connective tissue
What is a fibroblast?
Angiogenesis
The formation of new blood vessels
Granulation tissue
New capillaries that fill a wound 3-5 days after injury
Proliferative phase
In which phase does granulation tissue develop?
• Fill the wound 3-5 days after injury
• Produces a bacterium-inhibiting substance
• Produces scaffolding for re-epithelialization
What is the role of granulation tissue during wound healing?
Fibroblasts, myofibroblasts, endothelial cells, inflammatory cells, and new blood vessels, all connected by the extracellular matrix
What is granulation tissue made up of?
Fibroblasts decrease in number and are replaced by tissue rich in collagen
What occurs once the wound is covered by granulation tissue?
4-5 days after injury, starting at the wound edges then moving toward the center
When does epithelialization begin?
Enhances cell migration and cleanup as opposed to tissue that desiccates (dries up)
What is the benefit of a moist wound healing environment?
When myofibroblasts within the granulation tissue contract
When does wound contraction occur?
Reduces the size of the wound (Begins about 1 week after injury and can last for weeks)
What is the function of wound contraction?
• Maturation phase
• Begins after wound contraction, approximately 3 weeks after injury and continues for weeks to months
What is the final phase of wound healing, and when does it begin?
Maturation phase
Phase of wound healing characterized by remodeling and realignment of collagen fibers along tension lines
• Bleeding occurs after injury and platelets form clot to control bleeding
• Macrophages and neutrophils clean wound and modulate wound healing
• Release of growth factors
Briefly summarize the inflammatory phase of wound healing
• Fibroblasts and endothelial cells enter wound
• Formation of granulation tissue
• Epithelialization occurs under the scab until it falls off
• Wound strength increases considerably
Briefly summarize the proliferative phase of wound healing
• Remodeling and realignment of collagen fibers occurs
• Wound tissue gains the most strength
Briefly summarize the maturation phase of wound healing
• Cushing's disease
• Hypothyroidism
• Diabetes
• Hyperglycemia
• Chronic viral infections (FeLV, FIV)
• Orthopedic disease
• Neurological disease
• Poor nutritional status
• Obesity
Identify concurrent patient health issues that may delay healing
Alters tissue perfusion and O2 release
How can diabetes delay healing?
Interferes with defense against infection
How can hyperglycemia delay healing?
May lead to prolonged recumbency and associated decubital ulcers and poor wound healing
How can orthopedic or neurologic disease delay healing?
Low protein and albumin levels delay wound healing and strength
How can poor nutritional status delay wound healing?
Increased risk of wound infection and dehiscence due to decreased vascularization of fatty tissues impairing healing ability
How can obesity delay healing?
Degree of contamination and the length of time the wound has been open
What is wound classification based on?
Clean wound
Wound that is atraumatic and surgically created under aseptic conditions
Clean-contaminated wound (GI tract, respiratory tract, urogenital tract)
Wound created by controlled, surgical entry into contaminated areas
Clean wound is surgically created under aseptic conditions
Clean-contaminated wound is created by controlled, surgical entry into contaminated areas such as the GI or urogenital tract
What is the difference between a clean wound and clean-contaminated wound?
Contaminated wounds
Recent traumatic wounds with bacterial contamination from the pavement, soil, or saliva from a bite
Dirty wounds ( > 100,000 bacterial organisms/gram of tissue)
Older wounds with obvious infection often caused by an abscess, bite, contaminated puncture wound, or necrotic tissue
• Oncological radiation therapy
• Chemotherapy
• Corticosteroids
Identify concurrent factors that may delay wound healing
Can lead to tissue fibrosis and vascular scarring
How can oncologic radiation therapy delay wound healing?
Can suppress bone marrow function and decrease resistance to infection
How can chemotherapy delay wound healing?
Decrease the body's inflammatory response thereby increasing the risk for infection
How can corticosteroids delay wound healing?
Patient stabilization
What takes priority over wound care?
Wound lavage (LRS or 0.9% sodium chloride)
The washing out of a wound with a warm isotonic crystalloid fluid
To remove foreign or necrotic debris
Why is lavage used for wound management?
8 - 12 lbs per square inch using a pressure bag inflated to 300 mmHg
What is the appropriate lavage pressure strong enough to aid debris removal without damaging viable tissue?
Cytotoxic potential towards wound cells
What must be kept in mind when using antiseptic scrubs for wound care?
0.05% dilution (1:40 dilution of 2% chlorhexidine with water)
What is the proper dilution for a chlorhexidine solution?
0.1% dilution (1:100 dilution of 10% povidone-iodine with sterile saline)
What is the proper dilution for a povidone-iodine solution?
Remove contaminated, devitalized, or necrotic tissue and eliminate foreign debris from the wound
What is the goal of wound debridement?
Excision
The surgical removal of tissue from the body
Staged debridement
Used to remove necrotic tissue in wounds that may improve if given time to heal or may be removed if viability is lost
A mechanical (wet-to-dry) adherent primary bandage
Technique used during the inflammatory stage to non-selectively debride heavily contaminated wounds
Maggots
A biologic technique used for selective debridement of chronic wounds with poor tissue health
En bloc excision
Debridement technique that allows small wounds to be excised with primary closure
• Time since the injury
• Extent of foreign body contamination
• Degree of bacterial contamination
• Viability of the tissues
• Damage to neurovascular supply
• Location of the wound
• Availability of skin for closure
• Tension on the wound
Identify factors that can affect wound closure
Primary intention wound healing
Healing of a wound across a surgically closed incision using sutures, staples, or skin glue
• Direct apposition (wound edges close together)
• Primary intention wound healing
Surgical wounds are closed with _____ and will heal by _____
• Usually surgically created wounds
• Clean atraumatic lesions after wound lavage
• Small wounds with contamination can be excised en bloc and closed primarily
Which type of wounds typically undergo primary intention wound healing?
Delayed primary closure (closed before granulation tissue forms)
A wound older than 6-8 hours can be left open for 2-3 days to allow drainage and eliminate infection and then surgically closed
Secondary closure (third intention healing)
Wounds older than 6-8 hours are allowed to form healthy granulation tissue and then surgically closed
• Wounds older than 6-8 hours
• Infected or necrotic tissue
• Failed primary closure
Secondary closure is appropriate for which type of wound?