ceutics section 2 (questions only)

dibasic calcium phosphate is mainly used as

a. lubricant

b. opacifier disintegrant

c. filler/diluent

d. binder

c. filler/diluent

What is the purpose of Magnesium Stearate in the formulation of Purinethol tablet

a. Filler

b. Active pharmaceutical ingredient

c. Lubricant/antiadherent

d. disintegrant

c. lubricant/antiadherent

Which of the following is an advantage of the buccal formulation method of Fentora?

a. Shorter onset of action

b. Increases the amount of opioid being excreted

c. Decreases transmucosal absorption

d. Longer onset of action

a. shorter onset of action

Starch is the main disintegrant ingredient in the Decadron (dexamethasone) tablet formulation. The primary purpose of starch is to:

a. prevent sticking to die and punch

b. promote breakdown of particle aggregates

c. promote particle aggregation/cohesion in liquid state

d. facilitate flow of granules from hopper

b. promote breakdown of particle aggregates

Arrange each form of Coumadin from least to most rapidly released in the gastrointestinal fluid.

a. Granules, intact tablet, drug particles

b. Intact tablet, drug particles, granules

c. Intact tablet, granules, drug particles

d. Drug particles, granules, intact tablet

c. intact tablets, granules, drug particles

Manufacturing variables that would likely affect the dissolution of a prednisone tablet in the body include:

I. the amount and type of binder added

II. the amount and type of disintegrant added

III. the force of compression used during tableting

DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer:

A. if I only is correct

B. if III only is correct

C. if I and II are correct

D. if II and III are correct

E. if I, II, and III are correct

E. if I, II, and III are correct

what is the most likely reason for picking

excessive moisture in the granulation

what is the most likely reason for mottling

degraded drug

what is the most likely reason for capping

entrapment of airi

what is the most likely reason for sticking

excessive moisture in the granulation

which type of drug release is: drug is bound to a resin and released due to changes in pH

ion-exchange

which type of drug release is: drug is compressed into tabelts with a slowly soluble polymaer

matrix dissolution

which type of drug release is: drug is compressed into tablets with an insoluble polymer

matrix diffusion

which type of drug release is: drug is compressed into tablets with semipermeable membrane and laser drilled hole through which drug is transported out by convective flow

osmotic pumping

In which biopharmaceutics classification (BCS) can you find ritonavir (Low permeability with MW: 720 Da, Low solubility, water solubility: 1.1x10-4 mg/L at 25 degrees C)?

a. class 1

b. class 2

c. class 3

d. class 4

d. class 4

What is a disadvantage with using direct compression method?

a. Direct compression excipients possess inherent disintegration properties (microcrystallinecellulose)

b. Occurrence of unblending due to variability in API and excipients size/density

c. Faster dissolution compared to wet granulation

d. Fewer steps

b. Occurrence of unblending due to variability in API and excipients size/density

Which of the following statements is NOT TRUE about modified-release drug products?

a. Advising patients not chew on these products during administration

b. Delayed release products are not bioequivalent to Extended release product for the same active ingredient.

c. Advising patients to drink a full glass of alcohol with these medications for better absorption

d. Advising patients not to crush these products to maintain their physical integrity

e. They are commercially available in various solid dosage forms: ER tablets or Capsules

c. Advising patients to drink a full glass of alcohol with these medications for better absorption

Advantages to the manufacturer for tablet film coating when compared to sugar coating include:

I. shorter production times

II .less gross weight

III. lower incidence in coat chipping

DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer:

A. if I only is correct

B. if III only is correct

C. if I and II are correct

D. if II and III are correct

E. if I, II, and III are correct

E. if I, II, and III are correct

Agents that might be used to enteric-coated tablets include:

I. hydroxypropyl methylcellulose (HPMC)

II. carboxymethylcellulose (CMC)

III. cellulose acetate phtalate (CAP)

DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer:

A. if I only is correct

B. if III only is correct

C. if I and II are correct

D. if II and III are correct

E. if I, II, and III are correct

B. if only III is correct

Which of the following is not a coating agent used for Rilutek (Riluzole)?

a. Hypromellose Phthalate (HPMCP)

b. Titanium Dioxide

c. Hypromellose (HPMC)

d. Polyethylene Glycol 6000

a. HPMCP

The ingredient "yellow ferric oxide" act as __________________ in the formulation of Avigan tablets.

a. Surfactant

b. Plasticizer

c. Sweetener

d. Colorant

d. colorant

The main reason for the common use of titanium dioxide in pharmaceutical formulations as effective opacifier (to make the system opaque) is:

a. its high refractive index of 2.7

b. its high melting point of 1842 ºC

c. its high boiling point of 2972 ºC

d. Its molar mass of 79.866 g/mol (Da)

e. the presence of the two oxygen atoms in its structural formula

a. its high refractive index of 2.7

Hypromellose 2208 is an ingredient in all Glucophage (Metformin HCl) XR tablets. If this ingredient was removed from the medication what can we expect to change in the therapeutic effect or manufacturing process of Glucophage XR?

a. Product may cake and will struggle to freely flow during manufacturing.

b. Product would stick to machinery when being manufactured, causing an array of issues.

c. No therapeutic or manufacturing effect will be noticed.

d. The release of Glucophage XR when taken would be less controlled and result in a quicker release of the drug, removing the benefit of being an extended release tablet.

d. The release of Glucophage XR when taken would be less controlled and result in a quicker release of the drug, removing the benefit of being an extended release tablet.

Reasons for tablet coating include:

I. Masking the bitter taste or bad smell

III. Altering dissolution profiles (Controlled Release).

III. Preventing unwanted contact of personnel with the drug and enhancing appearance and elegance

DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer:

A. if I only is correct

B. if III only is correct

C. if I and II are correct

D. if II and III are correct

E. if I, II, and III are correct

E. I, II, and III are correct

What is the primary purpose of enteric coating of tablets?

a. To delay drug release until the large intestine

b. To improve taste

c. To release drug immediately in the mouth

d. To avoid inactivation by gastric acidity

d. to avoid inactivation by gastric acidity

Example of water insoluble poolymer for film coating include:

I. Ehylcellulose

II. Hydroxypropyl methylcellulose

III. Cellulose acetate phthalate (CAP)

DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer:

A. if I only is correct

B. if III only is correct

C. if I and II are correct

D. if II and III are correct

E. if I, II, and III are correct

A. if I only is correct

The following steps involved in hard gelatin capsule shells production?

I. Dipping

II. Spinning

III. Trimming

DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer:

A. if I only is correct

B. if III only is correct

C. if I and II are correct

D. if II and III are correct

E. if I, II, and III are correct

E. if I, II, and III are correct

The shells of soft gelatin capsules may be made elastic or plastic by the addition of?

A. Sorbitol

B. Providone

C. Polyethylene glycol

D. HPMC

a. sorbitol

High bloom strength gelatin is used in the manufacturing of?

I. Soft gelatin capsules

II. Hard gelatin capsules

III. All tablets

DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer:

A. if I only is correct

B. if III only is correct

C. if I and II are correct

D. if II and III are correct

E. if I, II, and III are correct

C. if I and II are correct

Which of the following capsules sizes has the largest capacity?

A. 5

B. 4

C. 1

D. 0

E. 000

E. 000

A pharmacist receives a prescription for 15 mg piroxicam capsules, qty. 48. A #1 capsule filled with piroxicam weighs 245 mg; a capsule filled with lactose weighs 180 mg. How much piroxicam and lactose are required for the prescription? Prepare sufficient powder for 50 capsules (2 extra).

A. 15 mg piroxicam + 165 mg lactose

B. 750 mg piroxicam + 9.00 g lactose

C. 750 mg piroxicam + 8.45g lactose

D. 15 mg piroxicam + 230 mg lactose

E. None of the above

C. 750 mg piroxicam + 8.45g lactose

What is the main role of the sugar spheres in Metadate CD capsules?

A. API

B. Filler

C. Disintegrant

D. Solution binder

b. filler

Why is Metadate CD preferred over IR Formulations of Methylphenidate HCl?

I. Higher adherence

II. Once a day dosing instead of multiple times per day

III. Less fluctuation of plasma concentration

DIRECTIONS: The question above contains three suggested answers of which one or more is correct. Select the best answer:

A. if I only is correct

B. if III only is correct

C. if I and II are correct

D. if II and III are correct

E. if I, II, and III are correct

E. if I, II, and III are correct

What abuse deterrent formulation strategy was used in Morphine/Naltrexone (Embeda) Capsules

A. Physico/Chemical effect

B. Aversion/Unpleasant effect

C. Prodrug/Implant effect

D. Agonist/Antagonist

d. agonist/antagonist

Which of the following is used as plasticizer in Norvir soft capsules?

A. Ritonavir

B. Gelatin

C. Polyoxyl 35 castor oil

D. Titanium dioxide

c. polyoxyl 35 castor oil

Which ingredient is responsible for the delayed release effect of Cardizem CD capsules?

A. Diltiazem

B. Talc

C. Eudragit RL 30 D

D. Simethicone emulsion, USP

c. eudragit RL 30 D

If the API of 125mg tablet decays by zero-order kinetics with a reaction rate constate kinetic of 0.5mg/hour, what is the amount of intact drug remaining after 3 days

89 mg

An orally Disintegrating Tablet (ODT) Dosage Form: is:

A) A tablet composed of active and/or inert ingredient(s), and a mixture of acids and sodium bicarbonate, which release carbon dioxide when dissolved in water.

B) A tablet that dissolves or melts quickly (usually within a matter of seconds) when it comes into contact with a liquid or saliva in the mouth.

C) A tablet dissolved in solvent and intended for administration by hypodermic injection.

D) A tablet intended for administration under the tongue.

E) A tablet intended for administration between the cheek and gum of the oral cavity. The active and/or inert ingredient(s) are usually absorbed through the oral mucosa

B) A tablet that dissolves or melts quickly (usually within a matter of seconds) when it comes into contact with a liquid or saliva in the mouth.

Considering this "secret" formula and procedure, the amount of Acetaminophen (in kg) required to produce1 million tylenol tablets is

A) 0.5 kg

B) 5 kg

C) 50 kg

D) 500 kg

E) 500,000 kg

d. 500kg

Which of the following is not an ingredient(s) in ibuprofen:

a. Maltose

b. Lactose

c. Croscarmellose sodium

d. Colloidal silicon dioxide

e. Hot Butter

f. A and E

g. B and C

h. None of the Above

f. A and E

Which of the following is true about the storage conditionsof DSUVIA (Sufentanil citrate) sublingual tablets?

a. DSUVIA should be stored at between 25-30 oC

b. DSUVIA should be stored away from light

c. DSUVIA can be stored in a bathroom cabinet

d. Because light only affects color, it does not matter if DSUVIA is protected from light

a. DSUVIA should be stored between 25-30 degrees

Dicalcium Phosphate Anhydrous is used in DSULVIA (sufentanyl) sublingual tablet as:

A. binder

B. disintegrant

C. filler

D. lubricant

c. filler

Which flavoring is used in the ODT tablet?

a. Mint

b. Orange

c. Strawberry

d. Ghost Pepper

e. Attack Helicopter

c. strawberry

What is the ingredient croscarmellose sodium used for in making acetaminophen tablets?

A. Disintegrant

B. Filler

C. Solubilizer

D. Coloring Agent

a. disintegrant

In Tylenol® (Acetaminophen) tablets, magnesium stearate is used as:

A. lubricant

B. disintegrant

C. colorant

D. binder

E. filler

A. lubricant

Sucralose (Trichlorosucrose, Splenda brand name) and mannitol (Resectisol®, Osmitrol®) are used in Vyvanse® (Lisdexamfetamine dimesylate) chewable tablets as

A. alternative diluents

B. alternative lubricants

C. alternative binders

D. alternative sweeteners

E. alternative disintegrants

D. alternative sweeteners

Which of the following is an abuse deterrent agent in Oxecta tablets?

I. Oxycodone

II. Polyethylene oxide

III. Sodium lauryl sulfate

II and III

How much of the 50 mg scored Purinethol tablets would you give to a poor metabolizer of Mercaptopurine, assuming that average patient would need 1 tablet.

I. Half tablet

II. One tablet

III. Two tablets

I. two tablets

which of the following is an advantage of the new formulation method of fentora

a. longer duration of actin

b. shorter duration of action

c. increases the amount of opioid being excreted

d. decreases transmucosal absorption

b. shorter duration of action

In the Fentora® (fentanyl citrate) buccal tablet formulation, citric acid is used:

I. to mainly increase buccal pH

II. to form API citrate salt to increase water solubility

III. to promote effervescence based on OraVescent® technology

II and III

What are the two ingredients that interact to

produce effervescence in Cetylev tablets in water

A) Acetylcystein and lemon

B) Acetycystein and sodium bicarbonate

C) Sodium bicarbonate and fumaric acid

D) Sodium bicarbonate and lemon

E) Sodium bicarbonate and edetate disodium

D) Sodium bicarbonate and lemon

Spritam® (Levetiracetam) Rapidly Disintegrating Oral 3D printed Tablet disintegrate between 2 and 27 seconds, with the average tablet disintegrating in 11 seconds in the mouth when taken with a sip of liquid. This is due to:

I. The manufacturing process using direct compression

II. The high solubility of the API and inactive ingredient

III. The manufacturing process using 3D printing

II and III

Which of the following excipients is used as an antioxidant to protect Spritam API (levetiracetam) from oxidative reactions. It reacts with free radicals and prevents further reactions by steric hinderance of tert-butyl group.

A. Colloidal silicon dioxide

B. Microcrystalline cellulose

C. Sucralose or Trichlorosucrose

D. Butylated hydroxyanisole

D. Butylated hydroxyanisole

What type of reaction is indicated by the following chemicalequation used to power the Tablet with sensor Abilify?

CuSO 4 (aq) + Mg(s) ---> Cu(s) + MgSO 4 (aq)

A. double replacement

B. single replacement

C. decomposition

D. combination

b. single replacement

Advantages to the manufacturer for tablet film coating when compared tosugar coating include:

I shorter production times

II less gross weight

III lower incidence in coat chipping

Select the best answer:

A. if I only is correct

B. if III only is correct

C. if I and II are correct

D. if II and III are correct

E. if I, II, and III are correct

E. if I, II, and III are correct

what capsule size has the smallest capacity

a. 5

b. 4

c. 2

d. 0

a. 5

The Bloom strength test data of a new gelatin is provided in the graph below. What is the best estimate of the Bloom strength of this gelatin

A) 0.7

B) 10

C) 70

D) 700

E) 7000

d. 700

The shells of soft gelatin capsules may be made elastic or plastic by the addition of?

A) Sorbitol

B) Povidone

C) Polyethylene glycol

D) HPMC

a. sorbitol

Which of the following is used as plasticizer in Norvir (Ritonavir) soft capsules?a. Ritonavir

b. Gelatin

c. Polyoxyl 35 castor oil

d. Titanium dioxide

c. polyoxyl 35 castor oil

Which of the following excipient is used as antioxidant in Norvir (Ritonavir) soft capsules to prevent oxidation of unsaturated fatty acid (Oleic acid, C18H34O2, C8H17CH=CH(CH2)7COOH, a light and oxygen sensitive organic solvent that is also fungistatic)?

a.Gelatin

b.Butylated hydroxytoluene

c.Polyoxyl 35 castor oil

d.Titanium dioxide

b.Butylated hydroxytoluene

What is the role of talc in the formulation of Danazol hard capsules?

a. To ensure disintegration of powder mixture (disintegrant)

b. Improve powder flow properties (glidant)

c. Improved flow properties and reduced powder adhesion to metal parts (lubricant)

d. Improve plug formation and compression (diluent)

b. Improve powder flow properties (glidant)

What is the main role of the sugar spheres in Metadate(Methylphenidate HCl) CD/ER capsules?

a) API

b) Filler

c) Disintegrant

d) Solution Binder

b. filler

Why is Metadate CD/ER (methylphenidate HCl) preferred over IR Formulations of Methylphenidate HCl?

a) Higher adherence

b) Once a day dosing instead of multiple times per day

c) Less fluctuation of plasma concentration

d) All of the Above

d. all of the above

Ammonio methacrylate copolymer and Methacrylic acid copolymer are used in Focalin (Dimethyphenidate HCl) XR Capsules as:

A. enzyme sensitive polymers to ensure bi-modal drug release profile

B. light sensitive polymers to bi-modal drug release profile

C. pH sensitive polymers bi-modal drug release profile

D. temperature sensitive polymers bi-modal drug release profile

c. pH sensitive polymers bi-modal drug release profile

A 15-year old patient with ADHD, when asked how he is taking his medication, he states that due to difficulty swallowing, he has been opening the capsules of Focalin XR and mixing them with chunky applesauce, which he chews before swallowing. Which of the following statement is CORRECT.

A. The new dose of Focalin XR is too high and should be reduced.

B. The patient is experiencing dose-dumping because he is opening the capsules.

C. The patient is experiencing dose-dumping because he is chewing the capsules content with applesauce.

D. The severity of the patient's ADHD has increased and he is suffering from anew onset anxiety disorder.

E. The patient is experiencing dose dumping because the capsules contents are interacting with the applesauce.

B. The patient is experiencing dose-dumping because he is opening the capsules.

Suppository base is that it should remain____ at room temperature.

a)solid

b)liquid

c)gaseous

d)plasma

a)solid

Polyethylene glycol is also known as

a)Witepsol

b)Massa estarinum

c)Macrogol

d)All of these

c. macrogol

If the density displacement factor for zinc oxide is exactly 4.44 (instead of 4), and the suppository mold holds 2.0 g of cocoa butter, The respective amount of zinc oxide and cocoa butter required to make these 12 suppositories is:

A) ZnO: 0.36 grams Cocoa butter: 2.3 grams

B) ZnO: 3.6 grams Cocoa butter: 2.3 grams

C) ZnO: 0.36 grams Cocoa butter: 23 grams

D) ZnO: 3.6 grams Cocoa butter: 23 grams

E) ZnO: 3.6 grams Cocoa butter: 24 grams

D) ZnO: 3.6 grams Cocoa butter: 23 grams

Most commercial vaginal suppository use abase of:

A) beewax

B) cocoa butter

C) glycerin

D) glycerinated gelatin

E) polyethylene glycol

E) polyethylene glycol

In quality control of suppository base, which parameter estimates the average molecular weight of the fatty acid ester composition of the base?

A) Iodine value

B) Acid value

C) Saponification value

D) Water activity

C) Saponification value

If a bottle of tablets has an expiration date of "Dec 2023", the pharmacist may continue to dispense the product

A) up to 1 year after the expiration date

B) only through January 31, 2022

C) only through December 15, 2022

D) only through December 31, 2023

E) if the pharmacist informs the patient to discard unused tablets in 6 months

D) only through December 31, 2023

A sweetener that is widely employed in chewable tablet formulas is

A) aspartame

B) glucose

C) lactose

D) mannitol

E) sucrose

D) mannitol

United States Pharmacopeia (USP) tests for ensuring the quality of drug products in tablet form include all of the following EXCEPT.

A) disintegration

B) dissolution

C) hardness and friability

D) content uniformity

E) weight variation

C) hardness and friability

The United States Pharmacopeia (USP) content uniformity test for tablets is used to ensure which of the following qualities?

A) Bioequivalency

B) Dissolution

C) Potency

D) Purity

E) Toxicity

C) Potency

Which one of the following statements concerning tablet dissolution is NOT true?

A) Disintegration precedes dissolution

B) In vivo disintegration is usually a good predictor of dissolution

C) Changing a drug's crystalline state may change dissolution rates

D) Increasing tablet compression force will increase dissolution

E) Micronization of drug powder will decrease dissolution time

D) Increasing tablet compression force will increase dissolution

Which of the following is NOT a function of the lubricant in a tablet formulation?

A) Improving flow properties of granules

B) Reducing powder adhesion onto the dies and punches

C) Improving tablet wetting in the stomach

D) Reducing punch and die wear

E) Facilitating tablet ejection from the die

C) Improving tablet wetting in the stomach

Dose dumping is a problem in the formulation of

A) compressed tablets

B) modified-release drug products

C) hard gelatin capsules

D) soft gelatin capsules

E) suppositories

B) modified-release drug products

Which of the following capsules sizes has the largest capacity?

A) 5

B) 4

C) 1

D) 0

E) 000

E) 000

The shells of soft gelatin capsules may be made elastic or plastic-like by the addition of

A) sorbitol

B) povidone

C) polyethylene glycol (PEG)

D) lactose

E) hydroxypropyl methylcellulose (HPMC

A) sorbitol

For each of the tablet processing problem listed below, SELECT/MATCH the most likely reason for the condition.

A) Excessive moisture in the granulation

B) Entrapment of air

C) Tablet friability

D) Degraded drug

E) Tablet hardness

Picking
Mottling
Capping
sticking

10-A. Picking
11-D. Mottling
12-B. Capping
13-A. sticking. Picking
11-D. Mottling
12-B. Capping
13-A. Sticking

For each of the tablet processing problem listed below, SELECT/MATCH the most likely reason for the condition.

A) Excessive moisture in the granulation

B) Entrapment of air

C) Tablet friability

D) Degraded drug

E) Tablet hardness

Mottling

D) Degraded drug

For each of the tablet processing problem listed below, SELECT/MATCH the most likely reason for the condition.

A) Excessive moisture in the granulation

B) Entrapment of air

C) Tablet friability

D) Degraded drug

E) Tablet hardness

Capping

B) Entrapment of air

For each of the tablet processing problem listed below, SELECT/MATCH the most likely reason for the condition.

A) Excessive moisture in the granulation

B) Entrapment of air

C) Tablet friability

D) Degraded drug

E) Tablet hardness

Sticking

A) Excessive moisture in the granulation

MATCH the lettered formulation design that best describes the mechanism of drug release from each of the following sustained-release drug delivery systems

A) Encapsulated dissolution

B) Ion-exchange

C) Matrix diffusion

D) Matrix dissolution

E) Osmotic pumping

Drug is bound to a resin and released due to changes in pH

B) Ion-exchange

MATCH the lettered formulation design that best describes the mechanism of drug release from each of the following sustained-release drug delivery systems

A) Encapsulated dissolution

B) Ion-exchange

C) Matrix diffusion

D) Matrix dissolution

E) Osmotic pumping

Drug is compressed into tablets with a slowly soluble polymer

D) Matrix dissolution

MATCH the lettered formulation design that best describes the mechanism of drug release from each of the following sustained-release drug delivery systems

A) Encapsulated dissolution

B) Ion-exchange

C) Matrix diffusion

D) Matrix dissolution

E) Osmotic pumping

Drug is compressed into tablets with an insoluble polymer

C) Matrix diffusion

MATCH the lettered formulation design that best describes the mechanism of drug release from each of the following sustained-release drug delivery systems

A) Encapsulated dissolution

B) Ion-exchange

C) Matrix diffusion

D) Matrix dissolution

E) Osmotic pumping

Drug is compressed into tablets with semipermeable membrane and a laser drilled hole through which drug is transported out by convective flow

E) Osmotic pumping

True statements, about the function of excipients used in tablet formulations include:

I. binders promote granulation during the wet granulation process.

II. glidants help to promote the flow of the tablet granulation during manufacture.

III. lubricants help the patient to swallow the tablets.

I. binders promote granulation during the wet granulation process.

II. glidants help to promote the flow of the tablet granulation during manufacture

The prime purpose for which of the following types of coating may be to mask the bitter taste of an orally administered drug?

I. Enteric

II. Film

III. Sugar

II. Film

III. Sugar

The rectal route of administration of drug may be preferred over the oral route for some systemic-action because

A) the drug does not have to be absorbed

B) absorption is predictable and complete

C) a portion of the absorbed drug does not pass through the liver before entering the systemic circulation

D) inert binders, diluents, and excipients cannot interfere with absorption

E) the dissolution process is avoided

C) a portion of the absorbed drug does not pass through the liver before entering the systemic circulation

A satisfactory suppository base must meet all of the following criteria EXCEPT

A) it should have a narrow melting range

B) it should be nonirritating and nonsensitizing

C) it should dissolve or disintegrate rapidly in the body cavity

D) it should melt below 30 degrees C

E) it should be inert

D) it should melt below 30 degrees C

Starch is the main disintegrant ingredient in the Decadron® (Dexamethasone) IR tablet formulation. The primary purpose of starch is to:

A. Promote particle aggregation/cohesion in liquid state

B. Prevent sticking to die and punch

C. Facilitate flow of granules from hopper

D. Promote break down of particle aggregates

D. Promote break down of particle aggregates

Which of the following is the active ingredient of Methylin® (Methylphenidate HCl) Chewable IR tablets?

A. Methylphenidate HCl

B. Aspartame

C. Microcrystalline Cellulose

D. All of the Above

A. Methylphenidate HCl

Which two ingredients serve as both glidants and anti-adherent agents in Nucynta® (Tapentdol) tablets?

A. talc and magnesium stearate

B. polyethylene glycol and titanium dioxide

C. microcrystalline cellulose and Lactose monohydrate

D. croscarmellose sodium and providone (PVP)

A. talc and magnesium stearate

Which of the following is not a coating agent used for Rilutek® (Riluzone) film coated tablets?

A. Hypromellose (HPMC)

B. Polyethylene Glycol 6000

C. Hypromellose Phthalate (HPMCP)

D. Titanium Dioxide

C. Hypromellose Phthalate (HPMCP)

The ingredients "titanium dioxide" and "yellow ferric oxide" act as __________________ in the formulation of Avigan® (Favipiravir) film coated tablets.

A. Surfactants

B. Sweeteners

C. Colorants

D. Plasticizers

C. Colorants

Which of the following statement is NOT TRUE about the administration of Oravig® (Miconazole)buccal tablet

A. Patients do not swallow the tablet

B. Patients does swallow the tablet

C. The tablet can be placed on upper gum

D. Patients can eat and drink while tablet is on gum

E. Tablets can be administered to unconscious patients

B. Patients does swallow the tablet

Prevacid Solutab® (Lansoprazole) orally disintegrating (ODT) delayed release tablet was made possible mainly due to the incorporation of the following pH sensitive inactive ingredient:

A. Mannitol

B. Crospovidone

C. Lactose

D. Polyacrylate

D. Polyacrylate

What are the advantages to using Suboxone® (buprenorphine/naloxone) sublingual films?

A. They have increased bioavailability as compared to the SL tablets

B. You can take a much lower dose when switching from SL tablets

C. They help to deter abuse

D. Both A and C are correct answers

D. Both A and C are correct answers

Acesulfame potassium (potassium salt of 6-methyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide,acesulfame K or Ace K, a synthetic calorie-free sugar substitute often marketed under the tradenames Sunett and Sweet One) is used in Suboxone® (buprenorphine/naloxone) sublingual films as:

A. alternative binder

B. alternative sweetener

C. alternative diluent

D. alternative colorant

B. alternative sweetener