Luca Liver Anatomy

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largest gland in the body

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1

largest gland in the body

liver

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2

blood supply of the liver

two - hepatic artery and portal vein

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3

hepatic artery

supplies 20% of blood and nutritional blood

oxygenated, nutrient poor

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4

portal vein

supplies 80% & functional blood

deoxygenated and nutrient rich

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5

how does blood exit the liver?

hepatic vein

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6

what blood flows through the portal vein?

all blood from GI and spleen

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7

liver functions as a

filter

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8

intrahepatic shunt

Direct connection between the portal vein and hepatic vein

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9

extrahepatic shunt

Connection between the portal vein that goes straight to the vena cava

(shunt outside the body)

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10

what happens to animals with shunts?

may not be able to metabolize nutrients

stunted

healthy or vomiting

hepatic encephalopathy

slow to metabolize drugs

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11

cell types in the liver

hepatocytes

endothelial cells

kupffer cells

stellate cells

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12

hepatocytes

main cell type

produce bile

synthesize of proteins, carbs, lipid metabolism and detox

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13

kupffer cells

macrophages in sinusoids

screen plasma for escaped microbes from gut, remove senescent RBCs, particulates

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14

stellate cells

in the space of Disse

important in Vitamin A storage

fibrogenic

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15

flow of bile

in canaliculi

collecting into bile ducts

drain into common bile duct

into duodenum

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16

functional unit of the liver

lobule

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17

portal tract

hepatic artery, portal vein, bile duct

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18

what is in the middle of the lobule?

central vein

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19

how does blood leave the lobule?

central vein

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20

what is the hepatic sinusoid lined by and contains what?

endothelial cells and contains macrophages

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21

what is drained by lymphatic vessels?

space of disse

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22

function of the microvilli

help absorb substances from the blood and aid in secretion of plasma proteins

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23

what does the hepatocytes excrete?

bile acids and waste material into the canaliculi through basolateral surface

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24

Hepatocytes absorb

toxins, chemicals, drugs and nutrients from Sinusoidal blood before they enter the hepatic vein

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25

how the lobule zones differ?

oxygen concentration and metabolic functions

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26

Where are bile acids stored?

gallbladder and emptied into bile duct that is regulated by hormones

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27

what system is the kupffer apart of?

reticuloendothelial systems that filters blood

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28

stellate cells - contains?

numerous vitamin A lipid droplets, constituting the largest reservoir of vitamin A in the body

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29

stellate cells - hepatic injury and chronic disease

these cells transform into myofibroblast-like cells to generate scar tissue

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30

consequence of intrahepatic shunt

blood rapidly exits the liver before it can be processed

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