pharm finls aghhh pt 2

Adamantane used for?

flu A

Adamantane MOA?

stops M2 protein = bad uncoating

Amantidine, Rimantidine which group?

Adamantane

Amantidine brand?

Symmetrel

Rimantidine brand?

Flumadine

Neuraminidase inhibitor used for?

flu A and B

Neuraminidase inhibitor MOA?

stops enzyme = can’t cut “sticky” host cell area = virus can’t spread

Oseltamivir, Zanamivir which group?

Neuraminidase Inhibitor

Oseltamivir brand?

Tamiflu

Zanamivir brand?

Relenza

Interferon used for?

Hep B and C

Interferon MOA?

activates RNA cleaver (pegloticase)

Peg alpha 2a brand?

Roferon

Interferon ADV

low WBC

Transcription inhibitor used for?

Hep B and C

Transcript inhibit. Nucleoside analogs MOA?

increase mutation = bad mutation = stops spread

Ribavirin which group?

Nucleoside analog

Transcript inhibit. Nucleotide analogs MOA?

inhibits DNA polymerase = no replication

Transcript inhibit. Protease inhibitor MOA?

stops protease = no cleavage = no transcription

Remdesivir (Veklury) which group?

Nucleotide analog

Remdesivier used for?

COVID

Paxlovid which group?

peptodomimetic inhibitor
(nirmatrelvir) and an HIV-1 protease inhibitor

Paxlovid MOA?

stops viral replication

Acyclovir (Zovirax) and Famicyclovir (Famvir) used for?

Herpes 1 and 2

Valacyclovir (Valtrex) used for?

Herpes 1

Acyclovir (Zovirax) and Famicyclovir (Famvir) MOA?

stops viral DNA synthesis

Acyclovir to Valacyclovir?

plus ester group

Cidofovir and Ganciclovir MOA?

stops virus DNA polymerase

Trifluridine used for?

conjuctivitis from herpes 1 and 2

HIV attacks? and what count is vulnerable

CD4 lymphocytes, at 200/mm²

NRTI used for?

HIV 1 and 2

NRTI MOA?

prodrugs stops revere transcriptease

ZIdovudine, Lamivudine which group?

NRTI

NNRTI MOA?

noncompetitive RTI