NSCLC Targeted therapy

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11 Terms

1
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EGFR Exon 19 deletion of exon 21 L858R substitution

Osimertinib

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EGFR alterations (G719X, L861Q, S768I)

Afatinib

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EGFR Exon 20 insertion mutation

Amivantamab-vmjw (Rybrevant) + carboplatin + pemetrexed

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ALK rearrangement

Alectinib (Alecensa)

Brigatinib (Alunbirg)

Lorlatinib (Lorbrena)

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ROS1 

Entretinib (Rozlytrek)

Crizotinib (Xalkori)

Reptotrectinib (Augtyro)

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BRAF point mutations

Dabrafenib (Tafinlar) + Trametinib (Mekinist)

Encorafenib (Braftovi) + Binimetinib (Mektovi)

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MET exon 14 (METex14)

Capmatinib (Tabrecta)

Tepotinib (Tepmetko)

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RET gene rearrangements

Selpercatinib (Retevmo)

Pralesetinib (Gavreto)

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KTRK fusion protein positive

Larotectinib (Vitrakvi)

Entrectinib (Rozlytrek)

Repotrectinib (Augtyro)

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KRAS G12C inhibitor

Sotorasib (Lumakras)

Adagrasib (Krazati)

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HER2+ mutation

FAM-trastuzumab deruxtecan (enhertu)

Trastuzumab emtansine