08: Cellular Adhesion and Endocytosis

Phagocytosis

Engulfing of a large molecule

Pinocytosis

Sampling of the extracellular environment via small vesicles

Receptor mediated endocytosis

Endocytosis modulated by clathrin coated membranes

Other proteins that can assist in receptor mediated endocytosis

COP I and COP II

CAM

Cell adhesion molecules; a category that spans many families

Common CAM families

• Ig

• Cadherins

• Integrins

• Selectins

Anchoring junction

Link via intermediate filaments

Occluding junction

Dam that asserts polarity and seals cells together at apical surface

Channel forming junctio

Provides passageway for small molecules and ions to pas from cell to cell

Signal relaying junction

Cellular junction that allows for protein mediated signal transduction (synaptic clefts!)

General type of cell adhesion

• Homotypic

• Heterotypic

Transmembrane adhesion protein that facilitates cell to cell attachment

Cadherins

Transmembrane adhesion protein that facilitates cell to matrix attachment

Integrin