WBC Exam - Non Malignant Disorders

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9 Terms

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Neutrophilia

10000-25000 / mcL

Acute - bacterial pathogenic stimulus, exercise, pain, extreme temps, epinephrine

Severe - leukemoid reaction

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Leukemoid reaction vs CML

Neutrophilia

CML - Ph t(9:22) with BCR/ABL1

Leukemoid - absent

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Hypereosinophilia

helminth parasites and allergies

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Basophilia

allergies, hypersensitivity, chronic myeloprolilferative diseases

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Infectious Mononucleosis

heterophile antibodies + = EBV

heterophile antibodies - = CMV or other infection

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Alder Reilly

large granules in cytoplasm of leukocytes associated with mucopolysaccharidosis

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Chediak-Higashi Syndrome

defects in granule morphogenesis

peroxidase positive bodies (fusion of primary granules) and giant lysosomes

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May Hegglin

granulocytes with Dohle bodies like inclusions consisting of RNA from rough ER

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Gaucher Disease

Deficiency of b-glucosidase needed to break down glucocerebroside resulting in lipid accumulation in macrophages