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Conduction
•nerve fibers conduct sensory and motor information up and down the spinal cord
Neural integration
•spinal neurons receive input from multiple sources, integrate it, and execute appropriate output (for example, bladder control)
Locomotion
spinal cord contains central pattern generators: groups of neurons that coordinate repetitive sequences of contractions for walking
Reflexes
involuntary responses to stimuli that are vital to posture, coordination and protection
Spinal cord
cylinder of nervous tissue that arises from the brainstem at the foramen magnum of the skull
•cervical, thoracic, lumbar, and sacral regions
spinal cord is divided into these 4 regions
Cervical enlargement
gives rise to nerves of upper limb
Lumbosacral enlargement
•gives rise to nerves of pelvic region, lower limbs
Medullary cone (conus medullaris)
inferior point of cord
Cauda equina
bundle of nerve roots that occupy the vertebral canal from L2 to S5; resembles a horse tail
Meninges
three fibrous membranes that enclose the brain and spinal cord
First-order neuron
detects stimulus and transmits signal to spinal cord or brainstem
Third-order neuron
carries the signal the rest of the way to the sensory region of the cerebral cortex
Second-order neuron
•continues to the thalamus at the upper end of the brainstem
Gracile fasciculus
•carries signals from midthoracic and lower parts of body
Cuneate fasciculus
•carries signals from chest and upper limbs
spinothalamic tract
part of the anterolateral system that passes up the anterior and lateral funiculi of the spinal cord
Upper motor neuron
originates in cerebral cortex or brainstem and terminates on a lower motor neuron
Lower motor neuron
cell body is in brainstem or spinal cord; axon leads to muscle or other target organ
tectospinal tract
•begins in roof of midbrain (tectum), descends contralateral spinal cord as far as the neck
Nerve
a cord-like organ composed of numerous nerve fibers (axons) bound together by connective tissue
Endoneurium
•loose connective tissue external to neurilemma
Perineurium
•layers of overlapping squamous cells that wrap fascicles: bundles of nerve fibers
Epineurium
dense irregular connective tissue that wraps entire nerve
Sensory nerves
composed only of afferent fibers; carry signals from sensory receptors to the CNS
Motor nerves
composed only of efferent fibers; carry signals from CNS to muscles and glands
Mixed nerves
consist of both afferent and efferent fibers
Ganglion
cluster of nerve cell bodies outside the CNS
Posterior ramus
•innervates the muscles and joints in that region of the spine and the skin of the back
Meningeal branch
reenters the vertebral canal and innervates the meninges, vertebrae, and spinal ligaments
Shingles (herpes zoster)
•localized disease caused by the virus traveling down the sensory nerves by fast axonal transport when immune system is compromised
Cervical plexus
•in the neck, C1 to C5: supplies neck and phrenic nerves to the diaphragm
Brachial plexus
near the shoulder, C5 to T1: supplies upper limb and some of shoulder and neck
Lumbar plexus
•in the lower back, L1 to L4: supplies abdominal wall, anterior thigh, and genitalia
Sacral plexus
•in the pelvis, L4, L5, and S1 to S4: supplies remainder of lower trunk and lower limb, including sciatic nerve
Dermatome
a specific area of skin that conveys sensory input to a spinal nerve