Integrated Rheumatology Review

A complete set of vocabulary terms and definitions derived from the Integrated Rheumatology lecture, covering auto-antibodies, pathology classifications, and clinical syndromes.

Homogeneous Pattern

ANA fluorescence pattern associated with anti-dsDNA and anti-histone antibodies.

Speckled Pattern

ANA fluorescence pattern associated with anti-Ro, anti-La, anti-Jo-1, and anti-U1-RNP antibodies.

c-ANCA

Cytoplasmic staining of granulocytes associated with PR-3.

p-ANCA

Perinuclear staining associated with MPO (Myeloperoxidase).

Lupus Nephritis Class III

Focal Lupus Nephritis defined as glomerulonephritis involving $<50\%$ of all glomeruli.

Lupus Nephritis Class IV

Diffuse Lupus Nephritis involving $\ge 50\%$ of all glomeruli, commonly showing subendothelial diffuse immune deposits known as Wire-loop lesions.

Lupus Nephritis Class VI

Advanced Sclerosing Lupus Nephritis, the terminal stage where $\ge 90\%$ of glomeruli show global sclerosis.

Lofgren Syndrome

A manifestation of sarcoidosis characterized by bilateral hilar lymphadenopathy.

Sarcoidosis Stage 1

Radiographic findings showing bilateral hilar lymph nodes (LN).

Sarcoidosis Stage 4

Radiographic findings showing pulmonary fibrosis.

CREST Syndrome

A form of scleroderma defined by Calcinosis cutis, Raynaud's phenomenon, Esophageal dysmotility, Sclerodactyly, and Telangiectasia.

Raynaud's Color Sequence

The vascular progression from White (vasoconstriction) to Blue (cyanosis) to Red (reactive hyperemia).

Hydroxychloroquine (HCQ)

The drug of choice in pregnancy for RA, noted for potential irreversible retinal damage and cardiotoxicity.

Sulfasalazine

An RA medication associated with male infertility and contraindicated in $G6PD$ deficiency.

Meltzer’s Triad

A clinical triad of purpura, arthralgia, and weakness, typically seen in Type II and Type III mixed cryoglobulinemia.

Takayasu Arteritis

Large vessel vasculitis affecting patients $<40$ years of age, characterized by blood pressure differences between upper limbs, RAS, and MI.

Buerger’s Disease

Vasculitis occurring in smokers $<35$ years of age, presenting with severe limb pain.

Granulomatosis with Polyangiitis (GPA)

Formerly Wegener's, characterized by a triad of URT (sinuses), LRT (cavity), and RPGN (crescents), associated with c-ANCA.

Behcet’s Disease

A vasculitis characterized by a triad of oral ulcers, genital ulcers, and uveitis, associated with HLA-B51.

Polymyositis

An inflammatory myopathy characterized by endomysial inflammation.

Dermatomyositis

An inflammatory myopathy characterized by perimysial inflammation, Gottron papules, Heliotrope rash, and Shawl sign.

Inclusion Body Myositis

A myopathy seen in elderly patients characterized by distal/proximal muscle involvement and rimmed vacuoles on histology.

MAGIC Syndrome

An acronym representing Mouth And Genital ulcers with Inflamed Cartilage.

Familial Mediterranean Fever (FMF)

A condition caused by the MEFC gene mutation (Pyrin), featuring periodic fever lasting 1-3 days and recurrent serositis.