Anaerobic Glycolysis

These flashcards summarize the key points about anaerobic glycolysis, including its processes, enzymes involved, and clinical implications.

What is the primary purpose of anaerobic glycolysis?

To regenerate NAD+ in the absence of oxygen.

What enzyme converts pyruvate to lactate during anaerobic glycolysis?

Lactate dehydrogenase.

What occurs to pyruvate in the TCA cycle under normal conditions?

Pyruvate is oxidized to carbon dioxide and water.

What is the Cori cycle?

A process where lactate produced in peripheral tissues is transported to the liver and converted back to glucose.

Why do red blood cells rely on anaerobic glycolysis?

They lack mitochondria, which prevents aerobic metabolism.

What clinical disorder is associated with deficiencies in the electron transport chain?

MELAS (mitochondrial encephalopathy lactic acidosis and stroke).

How does a deficiency in the electron transport chain lead to lactic acidosis?

It inhibits the regeneration of NAD+, leading to a shift towards anaerobic metabolism.

What role does NADH play in the conversion of pyruvate to lactate?

NADH is used to reduce pyruvate to lactate.