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what is a solvent?
substance that is able to dissolve other substances
what is a solute?
minor component in a solution that is dissolved in the solvent
what are two examples of solutes?
electrolytes and ions
how much of the body is intracellular fluid?
2/3
how much of the body is extracellular fluid?
1/3
what is the body's extracellular fluid divided into?
interstitial fluid and plasma
how is total body water divided?
extracellular fluid and intracellular fluid
what does total body weight depend on?
age, gender, and percentage body fat
what is filtration?
mass movement of water and solutes from plasma to the renal tubule
what is diffusion?
movement of particles from an area of high concentration to an area of low concentration
what is a clinical example of diffusion?
transport of most electrolytes and other particles through the cell membrane
what is osmosis?
movement of water through a semipermeable membrane to achieve an equilibrium of osmolarity
what is osmolarity?
number of milliosmoles in a liter of solution
what is osmolality?
number of milliosmoles in a kilogram of solution
what is an isotonic solution?
contains equal concentrations of solutes/water concentration on both sides
how are cells affected by an isotonic solution?
cells retain their normal size and shape
what is a hypertonic solution?
when there is more water and less salt inside the cell, it will flow out of the cell shrink by diffusion
how are cells affected by a hypertonic solution?
cells shrink
what is a hypotonic solution?
when there is more water and less salt outside the cell, it will flow into the cell by diffusion causing it to swell
how are cells affected by a hypotonic solution?
cells become bloated and burst (lyse)
what is isotonic (normotonic) fluid also known as?
isoosmotic
what is hypertonic fluid also known as?
hyperosmotic
what is hypotonic fluid also known as?
hypo-osmotic
what is fluid balance closely linked to/affected by?
electrolyte concentrations
what factors affect the amount and distribution of body fluids?
age, gender, and fat
what is fluid intake regulated through?
thirst drive
true or false-fluid loss occurs through several routes, such as the kidneys, skin, lungs, and intestinal tract
true
what is aldosterone?
"salt-retaining hormone" which promotes the retention of Na+ by the kidneys. na+ retention promotes water retention, which promotes a higher blood volume and pressure
what is antidiuretic hormone?
hormone secreted by the posterior pituitary gland to prevent the kidneys from expelling too much water
what are the two natriuretic peptides?
atrial natriuretic peptide (ANP)
brain natriuretic peptide (BNP)
does the renin angiotensin aldosterone system work to increase or decrease blood pressure?
increase blood pressure
what is released by the kidneys in response to low blood pressure?
renin
what is the normal sodium range?
136-145 mmol/L
what is the normal potassium range?
3.5-5 mEq/L
what ist he normal calcium range?
8.5mg/dl-10.5mg/dl
what is the normal magnesium range?
1.7-2.2 mg/dL
how does sodium often enter the body?
through foods and fluids such as smoked or picked foods, snack foods, and condiments
what electrolyte is the major cation of intracellular fluid?
potassium
what foods are highest in potassium?
meat, fish, many vegetables and fruits
what electrolyte helps to reduce blood pressure?
potassium
what electrolyte is commonly found in a variety of unrefined foods?
potassium
what electrolyte in excessive amounts can lead to health problems like high blood pressure?
sodium
what electrolyte is often present in high amounts in food products?
sodium
what electrolyte forms and keeps strong bones and teeth?
calcium
what does the absorption of calcium require?
active form of vitamin D
where is calcium stored?
in the bone
what is released when when more calcium is needed?
parathyroid hormone (PTH)
when excess calcium is present, what does the thyroid gland secrete?
thyrocalcitonin (TCT)
where is magnesium mostly stored?
bones and cartilage
what electrolyte assists with skeletal muscle contraction, carbohydrate metabolism, generation of energy stores, vitamin activation, blood coagulation, and cell growth?
magnesium
what is the pathophysiology of dehydration?
when fluid intake/retention does not meet the body's fluid needs, fluid volume deficit results (especially plasma volume)
what test assesses for dehydration?
skin turgor
true or false-mild dehydration is common among healthy adults, and is easily corrected or prevented by matching fluid intake with fluid output
true
what types of beverages can increase fluid loss?
beverages with caffeine
what are the 6 signs of temporary dehydration?
hot red skin (no sweat)
confusion
thirst
dry chapped lips
salty white residue around lips
fatigue
what are the 6 signs of chronic dehydration?
constipation
high blood pressure
dry skin
fatigue
achy joints
headaches
studies say what type of water hydration is 17% better than plain water?
alkaline water
in dehydration labs, is hematocrit elevated or depressed?
elevated
in dehydration labs, is serum osmolality elevated or depressed?
elevated (>295 mOsm/kg)
in dehydration labs, is serum sodium elevated or depressed?
elevated (>145 mEq/L)
in dehydration labs, is urine specific gravity elevated or depressed?
elevated (>1.030)
true or false-a single test is definitive for dehydration
false
what imaging assessment aids in the diagnosis of dehydration?
ultrasonography with basic echocardiography
why does poor perfusion occur when a patient is dehydrated?
due to excess fluid loss or inadequate fluid intake
when a patient is dehydrated, why are they at a higher risk for potential injury?
due to blood pressure changes and muscle weakness
how is dehydration treated?
restoring fluid balance through fluid replacement and drug therapy while preventing injury
what is the most important strategy to prevent recurrence of dehydration?
education
what is the best piece of advice when teaching a patient how to prevent dehydration?
drink small amounts of fluids as often as you can tolerate them, watch the clock and plan to drink at least a cup of fluid every 1 to 2 hours
how much water should a patient drink a day?
8 to 12 cups
true or false-in addition to plain water, patients should also drink fruit juices, soft drinks, flavored waters, decaffeinated coffee and tea, sports drinks, milk, and other beverages
true
what foods are high in fluids?
bouillon, broth-based soups, gelatin, fruit ices, popsicles, sherbet, milkshakes, and medical nutritional supplement drinks
patients should limit drinks with caffeine to how many a day?
only two a day
patients should maintain a daily fluid intake of at least how many mL?
1500 mL
what is fluid overload also referred to as?
hypervolemia
what complications can severe fluid overload cause?
heart failure and pulmonary edema
what electrolyte imbalances can fluid overload lead to?
dilution of sodium and potassium
what severe consequences can result from sodium and potassium dilution?
seizures, coma, death
what cellular activity is observed in hyponatremia?
excitable cellular activity
what system changes occur with hyponatremia?
cerebral, neuromuscular, intestinal, and cardiovascular changes
what position should a patient with fluid overload be in?
semi-fowler's
true or false-when in fluid overload, the patient should be kept warm to promote peripheral circulation
true
what is the first step in treating hyponatremia?
determine the cause
what therapies are used to treat hyponatremia?
drug therapy and nutrition therapy
what is the primary goal of managing fluid overload?
restoring normal fluid balance while preventing complications
what is euvolemic hyponatremia?
the water in the body increases but the sodium stays the same
what is hypervolemic hyponatremia?
sodium and water content in the body increases, with water retention being greater
what is hypovolemic hyponatremia?
water and sodium are both lost, but unequally, with the sodium loss being greater
what is pseudo hyponatremia?
falsely low serum sodium measurement (ex: bad blood draw technique)
what is translocational hyponatremia?
aka pseudohyponatremia that is
caused by excess of other solutes in the blood (glucose, mannitol, glycine, maltose, proteins, lipids)
what cerebral symptoms are associated with hypernatremia?
altered cerebral function
what muscular and cardiac issues may occur with hypernatremia?
muscle twitching and decreased cardiac contractility
how frequently should serum sodium be measured during fluid resuscitation for hypernatremia?
every 4 hours initially, then every 12 hours once stable
what therapies are used to treat hypernatreamia?
drug therapy and nutrition therapy
true or false-hypernatremia should be managed as a medical emergency
true
in the acronym "FRIED SALT," which represents the signs and symptoms of hypernatremia, what does the letter "F" stand for?
flushed skin and fever (low-grade)
in the acronym "FRIED SALT," which represents the signs and symptoms of hypernatremia, what does the letter "R" stand for?
restless, irritable, anxious, confused
in the acronym "FRIED SALT," which represents the signs and symptoms of hypernatremia, what does the letter "I" stand for?
increased blood pressure and fluid retention
in the acronym "FRIED SALT," which represents the signs and symptoms of hypernatremia, what does the letter "E" stand for?
edema peripheral and pitting
in the acronym "FRIED SALT," which represents the signs and symptoms of hypernatremia, what does the letter "D" stand for?
decreased urine output and dry mouth
in the acronym "FRIED SALT," which represents the signs and symptoms of hypernatremia, what does the letter "S" stand for?
skin flushed