hematology + oncology practice q's

Sickle cell disease involves an abnormality in which component?

Hemoglobin S

Platelets are derived from which type of cells?

Megakaryocytes

Which endogenous anticoagulant does factor V become insensitive to in factor V Leiden?

Protein C

Which lab monitors HIV patients for risk of opportunistic infections?

CD4 count

Which anemia is most likely to present with jaundice and dark urine?

Hemolysis

Which oncologic emergency is strongly associated with AML?

Leukostasis

A monoclonal spike of light chains is most consistent with which condition?

Multiple myeloma

Which immunoglobulin is most involved in cold agglutinin disease?

IgM

Which type of RBC is appropriate in an emergency before crossmatch?

Type O / Rh-negative

A 35-year-old man with CD4 180 and bilateral infiltrates. Most likely diagnosis?

Pneumocystis jirovecii

A 5-year-old boy with pallor, hepatosplenomegaly, and immature lymphocytes. Diagnosis?

Acute lymphoblastic leukemia (ALL)

Which mutation is associated with polycythemia vera?

JAK2 mutation

Reed-Sternberg cells are consistent with which malignancy?

Hodgkin Lymphoma

Which lab finding is most consistent with DIC?

Prolonged PT and aPTT

Which disorder leads to bleeding due to platelet dysfunction?

Von Willebrand Factor defect

Which coagulation factors are vitamin K dependent?

II, VII, IX, X

Which disorder is consistent with elevated indirect bilirubin?

Hemolytic anemia

Which test shows bone marrow response to anemia?

Reticulocyte count

Which lab finding is consistent with anemia caused by B12 deficiency?

Macrocytic, hyperchromic red blood cells

Which lab component measures oxygen-carrying capacity of blood?

Hemoglobin