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Population Genetics
The study of the genetic composition of populations
How and why allele frequencies change over time within and between populations
What approaches are used for population genetics?
Disease association studies; pharmacogenetics
Forensics; ancestry analysis
Conservation biology
Evolution/biological anthropology
Population
a group of interbreeding individuals that share a gene pool
Gene pool
set of all genes (alleles) in a population
HWE assumes
No selection (each allele has equal “fitness”)
Random mating
No migration in or out of the population
No mutation (no new alleles)
Large population size
Organisms are diploids
Evolution
changes in allele frequency of a population over (generational) time
If the assumptions of HWE are met…
allele frequencies don’t change over time
When allele frequencies are changing over time (generational)…
then evolution is happening