Oncogenes genetics

What chromosome are ABL oncogenes located on?

chromosome 9

what is the function of ABL oncogenes?

promote cell growth through tyrosine kinase activity

what kind of cancer is related to ABL oncogenes?

Chronic myelogenous leukemia (CML)

what chromosome is the ALK oncogene on?

chromosome 2

what is the function/activation of the the ALK oncogene?

encodes a receptor tyrosine kinase, regulates cell growth

what is the cancer associated with the ALK oncogene?

lymphomas

what chromosome is the BCL-1 oncogene located on?

chromosome 11

what is the function/activation of the BCL-1 oncogene?

encodes a cyclin that regulates CDK kinase and cell cycle progression

what kind of cancers are associated with the BCL-1 oncogene?

lymphoma, breast cancer, lung cancer

what chromosomes are the BCL-2,3,6 oncogenes located on?

chromosomes 18.19, and 3

what is the function/activation of the BCL-2,3,6 oncogenes?

block apoptosis (programmed cell death)

what cancers are involved in the BCL-2,3,6 oncogenes?

B-cell lymphomas and leukemias

what chromosome is the BRAF (RAF family) oncogene located on?

chromosome 7

what is the function/activation of the BRAF (RAF family) oncogene?

kinase signaling directing cell growth

what cancers are associated with the BRAF (RAF family) oncogene?

Non-Hodgkins lymphoma, colorectal cancer, melanoma

what chromosome is the EGFR oncogene on?

chromosome 7

what is the function/activation of the EGFR oncogene?

cell surface receptor that triggers cell growth through tyrosine kinase activity

what cancers are associated with the EGFR oncogene?

lung cancer

what chromosome is the ERBB-2 (HER2, neu) oncogene located on?

chromosome 17

what is the function/ activation of the ERBB-2 (HER2, neu) oncogene?

cell surface receptor that triggers cell growth through tyrosine kinase activity

what kind of cancer is involved in the ERBB-2 (HER2, neu) oncogene?

breast, salivary gland, and ovarian carcinoma

what does tyrosine kinase do?

class of enzymes that phosphorylate tyrosines in proteins

what chromosome is the MYC (c-Myc) oncogene on?

chromosome 8

what is the function/ activation of the MYC (c-Myc) oncogene?

transcription factors that promotes cell proliferation and DNA synthesis

what kind of cancer is involved in the MYC (c-Myc) oncogene?

leukemias and lymphomas, including Burkitt lymphoma

what chromosome is the N-MYC oncogene located on?

chromosome 2

what is the function/activation of the N-MYC oncogene?

cell proliferation and DNA synthesis

what kind of cancer is the N-MYC oncogene involved in?

neuroblastomas, retinoblastomas, and lung carcinomas

what chromosome is the RAS-H (HRAS) oncogene located on?

chromosome 11

what is the function/activation of the RAS-H (HRAS) oncogene?

G-protein, signal transduction

what kind of cancer is involved in the RAS-H (HRAS) oncogene?

bladder carcinoma

what chromosome is the RAS-K (KRAS, K-RAS) oncogene located on?

chromosome 12

what is the function/activation of the RAS-K (KRAS, K-RAS) oncogene?

G-protein, signal transduction, activating kinases, GLUT1 glucose transporter and propagates growth factors

what kind of cancer is involved in the RAS-K (KRAS, K-RAS) oncogene?

pancreatic, lung, ovarian, and bladder carcinoma

what chromosome is the PIK3CA (PI3K) oncogene located on?

chromosome 3

what is the function/activation of the PIK3CA (PI3K) oncogene?

kinase with phosphorylation activity

what kind of cancer is the PIK3CA (PI3K) oncogene associated with?

breast and cervical cancers

what chromosome is the RET oncogene located on?

chromosome 10

what is the function/activation of the RET oncogene?

receptor tyrosine activation

what kind of cancer is associated with the RET oncogene?

Medullary thyroid cancer, Hirschsprung's disease

what chromosome is the TERT (hTERT) oncogene located on?

chromosome 5

what is the function/activation of the TERT (hTERT) oncogene?

telomerase that maintains chromosome ends

what kind of cancer is associated with the TERT (hTERT) oncogene?

central nervous system, bladder, thyroid, and skin cancer