Solid Organ Transplant - Overview

viable organs for SOT

heart
lung
liver
kidney
pancreas
small bowel

1 part of the body to another

autotransplant

1 person to another

allotransplant

tissue from a different species

xenotransplant

transplanted into reciepient in the same place

orthotopic

transplanted into recipient in a different place

heterotopic

what organ transplants have the best outcome of living

liver
kidney

what needs to be tested before being considered for a SOT

HLA typing

assocation of genes found on short arm of chromosome 6 that play important role in immune recognition and response

HLA typing

compatibility assessed by number of mismathces of the donor

HLA typing

formed in response to non-self HLA exposure

HLA typing

pre transplant HLA DSA

contraindicated in donor transplant

post transplant DSA

development indicated failure of immunosuppression

quantified as a %
higher value = increase sensitization to MHC antigens

PRA

anount of pre-formed HLA antibodies in a recipeint vs general population

PRA

immune response causing inflammation and direct tissue destruction

allograft rejection

highest risk of rejection

heart
small bowel
lungs!

rejection caused by infilitration of allograft by lymphocytes and other inflammatory cells

t-cell mediated cellular rejection

rejection that occurs when circulating DSA are produced from plasma cells

antibody mediated rejection

regimen steps

inductions (prophylaxis)
maintenance (long-term)
rejection