CNS Drug Side Effects

Bupropion

Seizure risk; increased risk of suicide ideation in pediatric and young adults; dry mouth, insomnia, anorexia

Citalopram

Increased risk of suicide ideation in pediatric and young adults; cardiac arrhythmia (QTc prolonged); diarrhea, sleep disturbances, nausea

Escitalopram

Increased risk of suicide ideation in pediatric and young adults; cardiac arrhythmia (QTc prolonged); diarrhea, sleep disturbances, nausea

Fluoxetine

Increased risk of suicide ideation in pediatric and young adults; cardiac arrhythmia (QTc prolonged); diarrhea, sleep disturbances, nausea

Paroxetine

Increased risk of suicide ideation in pediatric and young adults; cardiac arrhythmia (QTc prolonged); diarrhea, sleep disturbances, nausea

Sertraline

Increased risk of suicide ideation in pediatric and young adults; cardiac arrhythmia (QTc prolonged); diarrhea, sleep disturbances, nausea

Desvenlafaxine

Increased risk of suicide ideation in pediatric and young adults; constipation, sleep disturbances, nausea, hypertension

Duloxetine

Increased risk of suicide ideation in pediatric and young adults; constipation, sleep disturbances, nausea, hypertension

Venlafaxine

Increased risk of suicide ideation in pediatric and young adults; constipation, sleep disturbances, nausea, hypertension

Amitriptyline

Increased risk of suicide ideation in pediatric and young adults; cardiac arrhythmia (QTc prolonged); constipation, sleep disturbances, nausea, hypertension

Doxepin

Increased risk of suicide ideation in pediatric and young adults; cardiac arrhythmia (QTc prolonged); constipation, sleep disturbances, nausea, hypertension

Nortriptyline

Increased risk of suicide ideation in pediatric and young adults; cardiac arrhythmia (QTc prolonged); constipation, sleep disturbances, nausea, hypertension

Mirtazapine

Increased risk of suicide ideation in pediatric and young adults; cardiac arrhythmia (QTc prolonged); sedation/drowsiness, increased appetite, constipation

Trazodone

Increased risk of suicide ideation in pediatric and young adults; priapism in men; sedation/drowsiness, hypotension

Atomoxetine

Increased risk of suicide ideation in pediatric and young adults; dry mouth, fatigue, mood swings, decreased appetite

Amphetamine-Dextroamphetamine

High risk of abuse and physical dependence; decreased appetite, weight loss, insomnia, nervousness

Dexmethylphenidate

High risk of abuse and physical dependence; decreased appetite, weight loss, insomnia, nervousness

Lisdexamfetamine

High risk of abuse and physical dependence; decreased appetite, weight loss, insomnia, nervousness

Methylphenidate

High risk of abuse and physical dependence; decreased appetite, weight loss, insomnia, nervousness

Modafinil

Skin rash that may progress to Stevens-Johnson Syndrome; anxiety, insomnia, nausea, headache

Phentermine

Rare pulmonary hypertension; insomnia, dry mouth, taste disturbances, tremors

Buspirone

Nausea, dizziness, excitation, headache

Alprazolam

High risk of sedation, respiratory depression, and death when taken with opioid or alcohol; physical dependence and abuse; drowsiness, sedation, ataxia

Clonazepam

High risk of sedation, respiratory depression, and death when taken with opioid or alcohol; physical dependence and abuse; drowsiness, sedation, ataxia

Diazepam

High risk of sedation, respiratory depression, and death when taken with opioid or alcohol; physical dependence and abuse; drowsiness, sedation, ataxia

Lorazepam

High risk of sedation, respiratory depression, and death when taken with opioid or alcohol; physical dependence and abuse; drowsiness, sedation, ataxia

Hydroxyzine

Increased risk of cardiac arrhythmia (QTc prolonged); drowsiness, sedation, dry mouth

Haloperidol

Increased risk of cardiac arrhythmia (QTc prolonged); dementia-related death in elderly patients; movement disorder, dry mouth, sedation, blurred vision

Lurasidone

Increased risk of cardiac arrhythmia (QTc prolonged); dementia-related death in elderly patients; sedation, weight gain, high blood glucose, high cholesterol

Olanzapine

Increased risk of cardiac arrhythmia (QTc prolonged); dementia-related death in elderly patients; sedation, weight gain, high blood glucose, high cholesterol

Quetiapine

Increased risk of cardiac arrhythmia (QTc prolonged); dementia-related death in elderly patients; sedation, weight gain, high blood glucose, high cholesterol

Risperidone

Increased risk of cardiac arrhythmia (QTc prolonged); dementia-related death in elderly patients; sedation, weight gain, high blood glucose, high cholesterol

Ziprasidone

Increased risk of cardiac arrhythmia (QTc prolonged); dementia-related death in elderly patients; sedation, weight gain, high blood glucose, high cholesterol

Aripiprazole

Increased risk of cardiac arrhythmia (QTc prolonged); dementia-related death in elderly patients; sedation, weight gain, high blood glucose, high cholesterol; akathisia

Eszopiclone

Increased risk of unusual sleep behavior (sleep-walking, sleep-driving, etc.); dizziness, taste disturbance

Zolpidem

Increased risk of unusual sleep behavior (sleep-walking, sleep-driving, etc.); dizziness, taste disturbance

Temazepam

Increased risk of unusual sleep behavior (sleep-walking, sleep-driving, etc.); dizziness, taste disturbance

Levetiracetam

Depression, drowsiness, asthenia (weakness)

Divalproex sodium

Suicide ideation, liver toxicity, pancreatitis, allergic reaction (hypersensitivity); drowsiness, nausea, hair loss, weight gain, bone loss

Gabapentin

Drowsiness, ataxia (clumsy movement)

Pregabalin

Drowsiness, ataxia (clumsy movement), dry mouth, constipation

Carbamazepine

Skin rash that may progress to Stevens-Johnson Syndrome (SJS) and death; dizziness, drowsiness, ataxia, nausea, vomiting

Oxcarbazepine

Skin rash that may progress to Stevens-Johnson Syndrome (SJS) and death; 1/3 of patients may have same reaction as carbamazepine; dizziness, drowsiness, ataxia, nausea, vomiting, low blood sodium

Lamotrigine

Skin rash that may progress to Stevens-Johnson Syndrome (SJS) and death; dizziness, drowsiness, ataxia

Phenytoin

Increased risk of cardiac arrhythmia (QTc prolonged); drowsiness, ataxia, gingival hyperplasia, osteoporosis

Topiramate

Metabolic acidosis; decreased sweating and hyperthermia; drowsiness, weight loss, visual disturbances, memory/concentration difficulties

Donepezil

Increased risk of cardiac arrhythmia (QTc prolonged) AND bradycardia; diarrhea, nausea, vomiting, abdominal discomfort

Memantine

Confusion, drowsiness, dizziness

Lithium carbonate

Nausea, thirst, hypotension, diarrhea, vomiting, tremor, ataxia

Carbidopa-levodopa

Nausea, drowsiness, dizziness, confusion, hallucination

Pramipexole

Drowsiness, dizziness, hallucination

Ropinirole

Drowsiness, dizziness, hallucination

Varenicline

Agitation, depression, suicidal ideation; nausea, hallucination, constipation, insomnia, headache

Sumatriptan

Increased risk of cardiovascular events (myocardial infarction, stroke); taste disturbance, oral/throat discomfort, dizziness

Bimatoprost

Stinging and burning of eyes; blurred vision

Latanoprost

Stinging and burning of eyes; blurred vision

Travoprost

Stinging and burning of eyes; blurred vision

Timolol

Stinging and burning of eyes; blurred vision

Brimonidine

Stinging and burning of eyes; blurred vision

Dorzolamide-timolol

Stinging and burning of eyes; blurred vision