unit 4 - Autonomic Nervous System

Adrenergic Agonist

Autonomic nervous system

Alpha

(Eye) Dilate pupil

Alpha 1

Blood vessels

Vasoconstriction

> BP

Beta 1

Heart

> heart rate

Beta 2

(Lungs) bronchodilation

Beta 1

Heart

> heart rate

Beta 2

Gastrointestinal

Relax (reduce gastric secretions and motility)

Beta 2

Bladder

Relax (< urination)

Beta 2

Uterus

Relax (decrease contractions)

Beta 2

Liver

Glucose release

> blood glucose

Alpha 1

Constriction

Alpha 2

Dilation ?

Beta 1

Increase heart

(Indirectly) > BP

Beta 2

Increase lungs ?

Bronchodilation

Beta 3

Increase bladder relaxation

-zosin

Alpha 1 blocker

-stigmine

Acetylcholinesterase inhibitor (AChEI)

-Chol

Muscarinic Cholinergic agonist

-enic-

Nicotinic

-olol

Beta 1 blocker

Antiarrythmics & Blood clotting drugs - cardiovascular system

Class I Sodium channel blocker

-mide

Class II antiarrhythmics are essentially all Beta-1 antagonists (beta blockers)

-olol

Class III Potassium channel blocker

-darone (long word like potassium)

Class IV Calcium channel blocker

Verapamil

(NSAIDs) Non-Steroidal Anti-Inflammatory Drugs

NSAIDs reduce:

• Inflammation

• Pain

• Fever

Antiplatelet

-grel (grinch-green slime- sticky-Antiplatelet)

Use - reduce heart attack

MOA - inhibit platelets which prevent blood from sticking to each other

Anticoagulant

-arin , -xaban

Thrombolytic

-plase (plaTe)

Carbonic anhydrase inhibitors

(–zolamide drugs) promote bicarbonate excretion, causing mild diuresis and metabolic acidosis.

ARBs Angiotensin II Receptor Blocker

(–sartan drugs) lower blood pressure by blocking angiotensin II receptors, causing vasodilation and reduced aldosterone release.

ACE = make less Ang II

ARB = Ang II can’t work

ACE inhibitors

(–pril drugs) lower blood pressure by blocking Ang I to Ang II conversion, causing vasodilation and reduced aldosterone.

“PRIL drugs prevent pressure, but cause cough, angioedema, and high potassium.”