urine anion gap

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Last updated 2:37 PM on 8/12/26
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Formula for urine anion gap?

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UAG = (Urine Na⁺ + K⁺) − Urine Cl⁻.

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What does a positive urine anion gap suggest in NAGMA?

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Low NH₄⁺ excretion → impaired renal acid excretion → RTA.

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What does a negative urine anion gap suggest in NAGMA?

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High NH₄⁺ excretion, as in GI bicarbonate loss/diarrhea.

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Why is urine chloride used indirectly to estimate NH₄⁺ excretion?

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NH₄⁺ is an unmeasured cation and is commonly excreted with Cl⁻.

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RTA vs VIPoma/secretory diarrhea: UAG?

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RTA → positive UAG; VIPoma/diarrhea → negative U