Week 1

Acute

• Days to months

• Symtoms fast and exacerbating

• Use immunosuppressants

Chronic

• Destruction is slow

• Can be hard to track/see symptoms/problems

Immune deficiency

too little immune system

Self way

too “much” immune system

Tissue remodeling

too long of immune system response

Hypersensitivity

immune system too vigilant

Graft rejection

immune system too effective

Antigen (Ag)

A substance that reacts with a specific component (receptor) of our immune system

Patten Recognition Receptors

Cellular proteins employed by the inmate immune system to identify pathogenic molecular patterns (PAMPs or DAMPs)

PAMPs

pathogen associate molecular patterns

DAMPs

damage associated molecular patterns

Somatically generated receipts

cellular proteins employed by the adaptive immune system to identify, adapt & remember specific pathogenic molecular patterns

Epitope (antigenic determinant)

a specific segment of an immunogenicity that interacts with immune cell receptors to elicit an immune response

Defensins

a large family of positively charged antimicrobial peptides known as effector molecules with broad activity produced in immune defense

Collectins

a family of “collagen”, calcium dependent antimicrobial peptides known as defense lectins produced in immune defense with branding specificity to sugar moieties and lipids