[PCOL] Part 2.2.2 - Autonomic Drugs - Sympathetic drugs - Sympatholytics

f. All

Sympatholytics:

a. Antagonists of sympathetic receptors

b. Prevent or reverse the actions of endogenously released NE or EPI or exogenously administered sympathomimetic agents

c. Classifications include direct acting and peripheral acting

d. a and b

e. b and c

f. All

c. Both true

1) Direct acting sympatholytics are alpha and beta blockers

2) Peripherally-acting sympatholytics are adrenergic neuronal blockers

a. Only 1 is true

b. Only 2 is true

c. Both true

d. Both false

e. None

Describe peripherally-acting sympatholytics except:

a. Adrenergic Neuronal Blockers

b. Drug that inhibit the normal physiologic release of norepinephrine

c. Inhibits the storage vesicle of NE

d. Inhibit the exocytosis NE

e. None

b.

Alpha Blockers:

a) Predominantly affect CV LOWERING PVR and BP

b) Convert the pressor action of sympathomimetics to a depressor response known as epinephrine reversal

Alpha Blockers:

a. Predominantly affect CV increasing PVR and BP

b. Convert the pressor action of sympathomimetics to a depressor response known as epinephrine reversal

c. Both

d. None

PhePhePhe

Phenoxybenzamine

Phentolamine

used for Pheochromocytoma

Non-selective alpha blockers.

“-zosins”

Prazosin

Doxazosin

Terazosin

Alfuzosin

Tamsulosin

Selective alpha1 blockers.

Yohimbine

Rauwolfscine

Selective alpha2 blockers.

b. Phentolamine

Reversible and competitive non-selective alpha blockers.

a. Phenoxybenzamine

b. Phentolamine

a. Phenoxybenzamine

Irreversible and noncompetitive non-selective alpha blockers.

a. Phenoxybenzamine

b. Phentolamine

b. Selective alpha1 blockers in general

For HTN and symptomatic relief of urinary retention in BPH patients.

a. Alpha blockers in general

b. Selective alpha1 blockers in general

c. Phentolamine

d. Phenoxybenzamine

e. Phentolamine and Phenoxybenzamine

f. Tamsulosin

Phentolamine

Phenoxybenzamine

For hypertension in patient with pheochromocytoma.

f. Prasozin

For essential HTN.

a. Alpha blockers in general

b. Selective alpha1 blockers in general

c. Phentolamine

d. Phenoxybenzamine

e. Phentolamine and Phenoxybenzamine

f. Prasozin

b. Selective alpha1 blockers in general

For urinary obstruction in BPH patients.

a. Alpha blockers in general

b. Selective alpha1 blockers in general

c. Phentolamine

d. Phenoxybenzamine

e. Phentolamine and Phenoxybenzamine

f. Tamsulosin

f. Tamsulosin

Greater efficacy for urinary obstruction in BPH patients.

a. Alpha blockers in general

b. Selective alpha1 blockers in general

c. Phentolamine

d. Phenoxybenzamine

e. Phentolamine and Phenoxybenzamine

f. Tamsulosin

c. Phentolamine

For reversible peripheral vasospasm (Raynaud syndrome) and erectile dysfunction

a. Alpha blockers in general

b. Selective alpha1 blockers in general

c. Phentolamine

d. Phenoxybenzamine

e. Phentolamine and Phenoxybenzamine

f. Tamsulosin

f. none

Adverse effects of phentolamine except:

a. postural or orthostatic hypotension

b. reflex tachycardia

c. arrhythmia

d. angina

e. diarrhea

f. none

c. Both

Adverse effects of Prazosin, Terazosin, Doxazosin.

a. Has initial effect of postural hypotension

b. Do not produce significant tachycardia

c. Both

d. None

f. All

beta-1 blockers → seen in the heart and juxtaglomerular cells

Beta1 blockers:

a. Lowers blood pressure

b. Reduced cardiac inotropy, chronotropy, and

dromotropy

c. RAAS inhibition: reduced renin release

d. a and b

e. b and c

f. All

b. Beta2 blockers

Increased airway resistance.

a. Beta1 blockers

b. Beta2 blockers

c. Alpha1 blockers

d. Alpha2 blockers

f. None

General effects of beta blockers except:

a. Decreased IOP

b. Inhibit lipolysis

c. Inhibit glycogenolysis

d. Decrease HDL

e. Local anesthetic action

f. None

NSTP

Nadolol

Sotalol

Timolol

Propranolol

Nonselective beta blockers.

CNBBEAAM

Celiprolol

Nebivolol

Bisoprolol

Betaxolol

Esmolol

Atenolol

Acebutalol

Metoprolol

Selective beta1 blocker.

a. Butoxamine

Selective beta2 blocker:

a. Butoxamine

b. Metoprolol

c. Acetbutolol

d. Bisoprolol

e. Propranolol

b. False

Butoxamine is selective beta2 blocker which do not have therapeutic application.

Butoxamine has a good therapeutic application

a. True

b. False

si ACE nag-CEL ng ballPEN at PIN na nakaLABEL sa CART

Acebutalol

Celiprolol

Penbutolol

Pindolol

Labetalol

Carteolol

B-blockers with intrinsic sympathomimetic activity.

PPALM

Pindolol

Propranolol

Atenolol

Labetalol

Metoprolol

B-blockers with local anesthesia — membrane stabilizing effect.

Beta blockers with alpha 1 blockade (mixed a and B blocker effects):

• Carvedilol

• Labetalol

B-blockers that are vasodilator through alpha 1 blockade.

Nebivolol

Beta blocker that enhances NO levels, thus acting as a vasodilator.

a. Selective beta1 blocker

Cardio selective

a. Selective beta1 blocker

b. Selective beta2 blocker

c. Nonselective beta blocker

e. b and c

Contraindicated with bronchial asthma due to enhance resistance.

a. Selective beta1 blocker

b. Selective beta2 blocker

c. Nonselective beta blocker

d. a and b

e. b and c

e. None

Therapeutic uses of beta blockers in the CVS except:

a. Generally, for HTN, in combination with a diuretic or vasodilator

b. Reduce incidence of MI thus used as anti anginal

c. Prophylaxis for Supraventricular Tachycardia (SVT) and Ventricular Tachycardia (VT)

d. Prophylaxis for angina pectoris

e. None

d. b and c

Beta blockers are the first line agent for hypertension in patients with history of myocardial infarction. They should be used in combination with

a. Vitamins

b. Diuretics

c. Vasodilators

d. b and c

e. a and b

f. All

f. All

Beta blockers used prophylaxis for angina pectoris:

a. Timolol

b. Propranolol

c. Metoprolol

d. a and b

e. b and c

f. All

c. Metoprolol tartrate

4 Approved beta blockers for treatment of CHF:

a) Carvedilol

b) Bisoprolol

c) Metoprolol SUCCINATE

→ Metoprolol TARTRATE is for post-MI, given 3x a day

d) Nevibolol

Approved beta blockers for treatment of CHF except:

a. Carvedilol

b. Bisoprolol

c. Metoprolol tartrate

d. Nevibolol

e. None

e. All

Beta blockers that is not contraindicated to patients with CHF and in fact approved for its treatment.

a. Carvedilol

b. Bisoprolol

c. Metoprolol succinate

d. Nevibolol

e. All

f. None

d. Nebivolol

The most cardio selective beta blockers which also causes vasodilation due to enhanced level of nitric oxide.

a. Carvedilol

b. Bisoprolol

c. Metoprolol tartrate

d. Nebivolol

e. a and c

Beta blockers used for glaucoma.

a. Timolol

b. Propranolol

c. Betaxolol

d. a and b

e. a and c

f. All

All

Propranolol:

a) For sympathetic symptoms of hyperthyroidism

b) Prophylaxis of migraine HA

c) Treatment of stage fright

Propranolol:

a. For sympathetic symptoms of hyperthyroidism

b. Prophylaxis of migraine HA

c. Treatment of stage fright

d. a and b

e. b and c

f. All

f. All

Beta blockers adverse effects

a. Majority may precipitate HF in patients with preexisting compromised cardiac function

b. Mask tachycardia associated with hypoglycemia

c. Mask the signs of developing hyperthyroidism

d. a and b

e. b and c

f. All

c. Nonselective B blocker

May cause bronchoconstriction

Contraindicated in patients with bronchial asthma and COPD

a. Selective B1 blocker

b. Selective B2 blocker

c. Nonselective B blocker

d. None

Propranolol adverse effects except:

a. Sedation

b. Sleep disturbances

c. Depression

d. None

e. All

e. None

(-) release of NE “GGB”

Guanethidine

Guanadrel

Bretylium

(-) Dopamine from entering its vesicle

Reserpine

Peripherally acting sympatholytics or adrenergic neuronal blockers except:

a. Reserpine

b. Guanethedine

c. Guanadrel

d. Bretylium

e. None

Reserpine

Inhibits storage of DA.

(-) release of NE “GGB”

Guanethidine

Guanadrel

Bretylium

Inhibit exocytosis of NE.

C. Tumor in enterochromaffin-like cells; oversecretes 5-HT -> Watery diarrhea, flushing, headache

Where is Carcinoid Syndrome located, what substance does it oversecrete, and what are its symptoms?

A. Tumor in pancreatic beta cells; oversecretes Insulin -> Hypoglycemia, tremors

B. Tumor in adrenal cortex; oversecretes Cortisol -> Moon face, buffalo hump

C. Tumor in enterochromaffin-like cells; oversecretes 5-HT -> Watery diarrhea, flushing, headache

D. Tumor in pituitary gland; oversecretes Prolactin -> Galactorrhea, amenorrhea

A. Phenoxybenzamine

What drug is "What To Do" (WTD) for managing Carcinoid Syndrome?

A. Phenoxybenzamine

B. Tamsulosin

C. Propranolol

D. Methyldopa

Baba Congestive Mortality

Bisoprolol

Carvedilol

Metoprolol succinate

Beta-blockers that decrease CHF mortality

D. Timolol and Betaxolol

Which two Beta Blockers are used topically for Glaucoma treatment?

A. Esmolol and Nebivolol

B. Propranolol and Nadolol

C. Carvedilol and Labetalol

D. Timolol and Betaxolol