Yap1 Oxidation Mechanism

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9 Terms

1
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What prevents Yap1 export during oxidative stress?

Oxidation blocks Crm1 interaction

2
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What domains contain Yap1 cysteines?

n-CRD and c-CRD

3
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Is Yap1 directly oxidised by H2O2?

No

4
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Which enzyme initiates Yap1 oxidation?

Gpx3

5
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Which cysteine in Gpx3 is oxidised?

Cys36

6
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What intermediate forms between Yap1 and Gpx3?

Mixed disulfide

7
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Which protein assists this interaction?

Ybp1

8
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What intramolecular bond forms in Yap1?

Cys303–Cys598

9
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What happens after stress ends?

Thioredoxin reduces disulfides and Yap1 exits nucleus