Anti malarials , Glycopeptide and sulfonamides

Two types of malaria causesing bacteria

And what do they effect

P. Falciform ( Effects the LIVER ) HYPOziote

P. Ovale and p . Vivae ( in the blood )

What specific type of animal causes malaria

And how is malaria diagnosed

Anophele mosquito

Blood smear

Anti malaria's given for p.ovale and vivae

If sensitive( not resistant )Chloroquine****

If resistant + Primaquine ( HYPOziotes) FOR THE SPORES

Anti malarial that is NOT GIVEN TO G6PD

Chloroquine

Sever malaria is given what drug

Artesunate

Uncomplicated p.flaciform takes what ani malarial

Artemether  - Lumefantrine

Prophylaxis for malaria

Doxycycline

Or atovaquane + proguanil

Vancomycin resistance mechanism

• resistance is due to D-Ala-D- lac (VRE)

Vancomycin spectrum and specific bacteria it is good against

ONLY gram ( +)

• Actinomyces - clostridium difficile

• first line for MRSA ****

Red man syndrome is causes by what in vancomycin use , and how is it managed

Prevent with slow infusion + antihistamines

(Red man syndrome is NOT an allergy , SLOW infusion fixes it )

Vancomycin is toxic to what organ , and what is monitored to prevent the toxicity of that organ

Nephrotoxic 🫘

MUST MONITOR THROUGH LEVELS

Oral vancomycin has 1 used , What is it

C . Diificile ( toxic megacolon )

Give me drug from the gylcopeptide class other than vancomycin

Teicoplanin : also in MRSA

Trimethoprim And Sulfamethoxazole MoA

Trimethoprim : dihhdrofolate reductase

• Sulfamethoxazole : blocks Dyhydropteroate synthase

Uses of TMP and SMX ( 4 uses )

• Toxoplasmosis prophylaxis

• Pneumocystis jirovecii pneumonia (PCP) ( TREATMENT AND PORPHYLAXIS )

• Nocardia ( opportunistic lung infections )

• Non complicated UTI

Toxoplasmosis treatment

sulfadiazine + pyrimethamine + locovorin

High yeild side effects of Trimethoprim

Hyperkalemia