Pang; Primary, Secondary, Tertiary Structures of Proteins

Which are bigger, peptides or proteins?

proteins

What is protein backbone composed of?

peptide and amine bonds (R3-N, R2-NH, R-NH2)

What are amino acids composed of?

CHON (carbon, hydrogen, oxygen, nitrogen)

What is a key factor to determine the structure and stability?

Side chains of amino acids

What order are alpha helix and beta sheet?

secondary protein structure

What is the main driver of the protein folding? (from primary to higher structure)

Noncovalent force (exception: Disulfide bond) - mainly H bonds and salt bridges

What amino acids can form ionic bonding?

Arg, Lys, His (+), Asp, Glu (-)

What drug example is doing protein degradation by targeting excessive or mutated proteins?

PROTAC (inhibitor, linker, e3 ligase ligand)