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tetrodotoxin
blocks VG Na+ channels @ axon hillock = no AP
latrotoxin
explosive release of ACH
omega conotoxin GVIA
blocks VG Ca2+ channels (no Ca2+ in axon terminal)
blocks in presynaptic neuron
botulinum toxin
blocks release of ACH - no muscle contraction
omega agatoxin GVIA
blocks VG Ca2+ channels in the presynaptic neuron
organophosphate
prevents degradation of ACH - left in cleft
prostigmine
inhibits ACH, left in cleft
curare
blocks nicotinic ACH receptor
alpha bungarotoxin
blocks nicotinic ACH receptor