10.1 · Measuring kidney function

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Last updated 5:02 AM on 8/9/26
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8 Terms

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Glomerular filtration rate (GFR)
Production of filtrate by the glomerulus, typically 125 ml/min; the best measure of overall kidney function
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How GFR is usually estimated
Serum creatinine concentration, considering age and sex
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Impractical alternative GFR measurement
Injected inulin
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BUN
Blood urea nitrogen, the concentration of urea in the blood
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What BUN indicates
Degree of glomerular filtration and urine-concentrating capacity
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Why BUN rises when tubular flow slows
Urea is reabsorbed from the nephron, so slower flow allows more urea to be reabsorbed back into the blood
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Plasma creatinine
Produced by the muscles, filtered at the glomerulus, and never reabsorbed
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Relationship of creatinine to GFR
If GFR decreases, plasma creatinine concentration increases, and vice versa