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bumps on head
telling of personality traits
phrenology
(pseudoscience) reading/measuring bumps on the skull
Edwin Smith Surgical Papyrus
first record writing about the brain
First medical book
The Canon of Medicine written by Persians
Trepanation
first attempt at brain surgery (a hole was made in a person's head to relieve pressure, pus, or to release demons)
The Canon of Medicine
divided into five books; essays on basic medical and physiological principles, list of medical substances, diagnosis and treatment of diseases, diagnosis and treatment of conditions, and compound remedies
dualism
mind and brain are separate
monism
the mind is what the brain does, they are one.
Wilhelm Wundt
first to study the mind as separate from other fields
Ultimate function of brain
thinking, logical reasoning, perceiving, remembering, etc
Charles Darwin
theory of how organisms changed over time with a changing environment
Jean Baptiste
proposed that organisms change within their own life to meet the pressures of their surroundings (giraffe example, neck getting longer to reach the tree in order to eat)
Postulate 1
Postulate 1= Variation within the population (population is a group of interbreeding members of the same species but variation in just about all aspects like size, color, resistance to disease, etc)
Postulate 2
-Postultate 2= Over reproduction (all organisms produce more offspring than can survive to reproduce, yet populations stay relatively stable.
Postulate 3
-Postulate 3= Competition (organisms compete for food, space, mates, etc)
Postulate 4
-Postulate 4= Advantage (those that happen to be able to compete more successfully tend to live longer, and produce more offspring and thereby pass on the traits that's helped them survive to their offspring, think of natural selection)
Postulate 5
-Postulate 5= Modification through descent (as the environment changes and applies different pressures, organisms modify through decent, change through generations) think of bodybuilder doesn't pass on big muscles to offspring
Biogeography
similar physical features in the same area

Positive eugenics
promoting high reproduction in humans with "good" genes (Darwin's cousin started)
Negative eugenics
removal of "bad" genes (sterilization in Hispanic community, Nazi genocide, etc)
CNS
brain and spinal cord
PNS
all nerves that lie outside cns to relay info between CNS and rest of body
Nerve
thousands of neurons wrapped together in a bundle that transmit electrical signals through different parts of body
Sensory neurons
neurons that receive information from the external world and convey this information to the brain via the spinal cord
Motor neurons
neurons that carry outgoing information from the central nervous system to the muscles and glands (to help u move)
Interneurons
CNS neurons that internally communicate and intervene between the sensory and motor neurons
Neuron
Transmit info throughout body (made up of proteins)
Parts of a neuron
Soma (cell body), dendrites(receive signals from other neurons), axon (transmits signals to other cells at synapses), terminal buttons (passes info across synapse in the form of a chemical messenger aka neurotransmitters)

How is info transmitted between neurons
presynaptic cell to postsynaptic cell
axoplasmic transport
movement of proteins, organelles, and other materials within an axon
antrograde direction
down terminal (from soma to button) like kinesin (retrograde is opposite like dynein, button to soma)
What do glial cells do
involved in support, replication, and communication,
types of glial cells
astrocytes, oligodendrocytes, microglia
astrocytes
(only in cns) brings in nutrients like glucose, helps in signals by cleaning because too much can cause some kind of excitement, (what its doing at synapse recycling and blocking it from leaving synaptic cleft) and helps protect blood-brain barrier
Oligodendrocytes
creates myelin for axons, aids in development (node of ranvier, bring in ions into the nodes,)
Microglia
immune function, removes dead neurons, overactive associated with diseases like autism and schizo, role in "pruning" (use it or loose it)
Where are proteins primarliy synthesized in neurons?
In the soma, particularly on ribosomes attachted to the rough endoplasmic reticulum
ependymal cell
line the fluid-filled ventricles of the brain and the central canal of the spinal cord CFS? Cerebral spinal fluid? (circulate fluid, regulate exchange, and support balance)
Glutamate
#1 excitatory neurotransmitter in brain
what is myelin made up of
80% lipids and 20% proteins
Schwann cell
glial cells in peripheral nervous system , creates myelin for neurons, creates pathways or regrowing axons after injury
Cells of the nervous system
Neuron, glia, blood brain barrier
Blood brain barrier
between cns and circulatory system helps to regulate the flow of nutrient rich fluid into the brain (selectively permeable)
Capillary in all of body but...
brain! (gaps that permit the free flow of substances into and out of the blood) glucose in and toxins out
GABA
inhibitory neurotransmitter
synaptic transmission
communication between neurons
Postsynaptic potentials
brief depolarization (on) or hyperpolarization (off)
How do neurotransmitters excert effects?
neurotransmitter molecules fit binding sites like a lock and keep excerpt effects by attaching to binding sites (outside is positive and inside is negative)
Synapse
the space between the terminal buttons of one neuron and the dendrites of the next neuron
Axodentritic synapes
slower as they are on the smooth surface of dendrites or dentrite spines

Axoaxonic synapses
faster as they are on the synapse between two terminal buttons

synaptic vesicle
small, hollow, beadlike structure found in terminal buttons, contains molecules of neurotransmitter
release zone
= region of interior of the presynaptic membrane of synapse to which synaptic vesicles attach and release their neurotransmitter into synaptic cleft
Exocytosis
cell secretes molecules of neurotransmitters
receptor activation
neurotransmitter molecules diffuese across synaptic cleft and attach to binding sites (postsynaptic receptors)
What happens after neurotransmitter binding?
receptors open neurotransmitter dependent ion channels
ionotropic vs metatropic receptors
direct vs indirect
Excitatory postsynaptic potential
sodium channel is most important source, depolarization
Inhibitory postsynaptic potential
hyperpolarizing
What happens when activity of excitatory synapses go up? And vise versa?
excitatory= rate of firing will increase and if activity if inhibitory synapses goes up, rate of firing will decrease
what happens to neurotransmitters after they cause polarization or depolarization?
Termination by two mechanisms:
1. reuptake= an extremely rapid removal of a neurotransmitter from the synaptic cleft by the terminal button
2. Enzymatic deactivation; accomplished by enzyme that destroys molecules of neurotransmitter (acetylcholinesterase deactivates acetylcholine)