Transplantation Immunology

This does not cover the entire slide set.

co-dominantly

how HLA genes are expressed

autograft

same individual at a different location

syngeneic

transferred between genetically identical individuals

allograft

transfer between genetically different members of the same species

xenografts

transfer between members of different species

direct recognition

donor APCs present to recipient T-cells and involve MHC I or II

indirect recognition

recipient APCs present to recipient T-cells and involve MHC II

chronic rejection timeline

weeks to years

chronic rejection

vascular connections

donor tissue replaced my ECM and scar tissue

mismatches of non-MHC genes

acute rejection timeline

2-4 weeks

acute rejection

vascular connections

edematous and inflamed donor tissue

MHC mismatches, especially MHC I

hyperacture rejection timeline

a few days

hyperacute rejection

no vascular connections

immune response involving complement, NK cells, and antibodies against vasculature

second set rejection

an immune response mediated by memory B cells and T cells

panel reactive antibody (PRA)

the percentage of the population that the recipient would reject a donation from

HLA cross match

a test that determines if a recipient will reject a donation based on blood-blood interaction; negative is desirable for a donation match

CYP inducer

a molecule that increases metabolism, therefore decreasing concentration of the drug

CYP inhibitor

a molecule that decreases metabolism, therefore increasing concentration of the drug

nadir creatinine

the lowest creatinine concentration; new normal for those who have received a kidney transplant