B- oxidation

7TM

is the receptor of adrenalin catecholamine , cortisol , clucagon that activates the lipolysis

brain and erythrocytes

.......... And ........... Cannot use the fatty acids to produce energy

long chain fatty adcis

fatty acids that need transporter to get into the mitochondria (carnitine )

very long fatty acid

fatty acid enter peroxisomes via an unknown mechanism for oxidation

tha half time of fatty acids

its about 1-3 minutes

long chain free fatty acid

FA whch is water insoluble and are combined with albumin

heart

80 % of its fuel is from b-oxidation

thiokinase

the enzyme that activates B-oxidation and needs 2ATP and CoASH to work

pyrophosphatase

ensures complet activation

carnitine

is synthesized from lysine and methionine in liver and kidney and responsible for transport fatty acid into mitochondria

types of carnitine

1- transferase I : out of mitochondria 2- acylcarnitine translocase 3- transferase II : in the mitochondria

crotonase

also called CoA hydratase enzyme and adds H2O to saturated double bond

thiolase

also called B-ketothiokinase and splits acyl coA into acetyl coA and acyl CoA which is shorter than 2 carbon atom

acetyl CoA

converted to several useful compounds such as : cholesterol , acetyle choline

acetoacetic acid

one of the keton bodies , it is the last 4 carbons remained from B-oxidation

hypoglycemia

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MCAD

is one of the highest of the inborn errors of metabolism 1%10,000