8/26 Injury Response Process Part 2

The lining up and adhesion of WBCs along capillary walls.

margination

What does histamine cause?

vasodilation and increased capillary permeability

Movement of neutrophils and RBCs from capillaries into injured tissue.

diapedesis

A substance released by neutrophils that signals the amount of phagocytic activity needed.

necrosin

What do macrophages do?

attack and engulf necrotic tissue through phagocytosis

Plasma and plasma proteins leaking from capillaries due to increased mpermeability.

exudate

What contributes to swelling after injury?

blood, exudate, inflammatory cells, and fluid accumulation

Pain causes muscle spasm, which increases swelling and lead to more pain.

pain-spasm cycle

What is the primary treatment goal immediately after injury?

limit swelling

What are the five classic signs of inflammation?

redness, swelling, tenderness, increased temperature, and loss of function

What modality is most commonly used during the Acute Inflammatory Phase?

cryotherapy

Why is cryotherapy used?

to reduce swelling

What is intermittent compression used?

to facilitate lymphatic removal of inflammatory byproducts and reduce swelling

Why perform pain-free ROM exercises during the acute phase?

to promote healing

When does the Fibroblastic repair Phase occur?

72 hours after injury through 3-6 weeks

What is the goal of Fibroblastic Repair Phase?

temporary tissue repair

Healing with minimal tissue gap and minimal scar formation.

primary intention healing

Healing of larger injuries requiring more granulation and scar tissue.

secondary intention healing

What triggers growth of a capillary network?

lack of oxygen

What do fibroblasts produce?

collagen