Pharmacogeriatrics GERO495

0.0(0)
studied byStudied by 0 people
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
Card Sorting

1/23

encourage image

There's no tags or description

Looks like no tags are added yet.

Study Analytics
Name
Mastery
Learn
Test
Matching
Spaced

No study sessions yet.

24 Terms

1
New cards

is the study of how the body interacts with administered substances for the entire duration of exposure

Pharmacokinetics

2
New cards

The four main parameters generally examined in pharmacokinetics are:

•Absorption

•Distribution

•Metabolism

•Excretion

3
New cards

is the study of a drug's molecular, biochemical, and physiologic effects or actions.

Pharmacodynamics

4
New cards

Distribution

Locations in the body a drug penetrates expressed as volume per weight (e.g. L/kg)

5
New cards

Bioavailability: the fraction of a drug dose reaching the systemic circulation

Absorption

6
New cards

Drug conversion to alternate compounds which may be pharmacologically active or inactive

Metabolism

7
New cards

Elimination

A drug’s final route(s) of exit from the body expressed in terms of half-life or clearance

8
New cards

Absorption is the process that brings a drug from the administration, e.g., tablet or capsule, into the  systemic circulation.

Absorption

9
New cards

Metabolic clearance of drugs by the liver may be reduced due to:

•Decreased hepatic blood flow

•Decreased liver size and mass

•Changes in liver structure and metabolism

10
New cards

Excretion

•Excretion is the process by which the drug is eliminated from the body.

•The kidneys play a crucial role in the elimination of drugs

11
New cards

•Decreased kidney size Decreased renal bloodflow

•Decreased number of functional nephrons Decreased tubular secretion

•Result:glomerular filtration rate (GFR)

•Decreased drug clearance: atenolol, gabapentin, H2 blockers, digoxin, allopurinol, quinolones

Effects of Aging on Kidney

12
New cards

•Time for serum concentration of drug to decline by 50% (expressed in hours)

Half-life

13
New cards

•The volume of serum from which the drug is removed per unit of time (mL/min or L/hr)

Reduced elimination ⇒ drug accumulation and toxicity

Clearance

14
New cards

•Review medications regularly and each time anew medication started, or dose is changed

•Maintain accurate medication records (include vitamins, OTCs, and herbals)

•“Brown-bag reviews”

Preventing Polypharmacy

15
New cards
16
New cards
17
New cards
18
New cards
19
New cards
20
New cards
21
New cards
22
New cards
23
New cards
24
New cards