renal function part 2 RAAS

what is RAAS Job

RAAS help regulate blood pressure, blood flow to and within kidney, sodium levels

when does RAAS turn on

its turned on in responds to changes in blood pressure and sodium content in plasma

low blood pressure or low sodium level

what is JGA job

it a cell that sense the changes in the afferent arteriole and help monitor conditions related to blood pressure and release renin when it is needed. watches blood pressure

where is macula densa located and what is its job

they located in the Distal convoluted tubule (DCT) and their job is to monitor the sodium concentration in the tubular fluid. watches sodiums

What two factors help turn RAAS on and off?

Blood pressure and Na⁺

When does RAAS come into action?

When blood pressure and/or Na⁺ are low

What structure senses the changes and causes renin release?

JGA

What does the JGA release?

Renin

RAAS helps the body retain sodium and water. true or false

true

What happens to blood volume when the body retains more water

It increases

Which organ produces angiotensinogen?

liver

Renin converts angiotensinogen into

Angiotensin I

What converts angiotensin I into angiotensin II?

ACE (Angiotensin-Converting Enzyme)

. What does angiotensin II cause what ?

1. blood vessels to Constrict

2. aldosterone to be secreted by adrenal cortex that cause sodium and water retention

3. increase ADH antidiuretic hormone secreted by hypothalamus and more water is retained so blood pressure goes up   

Which part of the adrenal gland secretes aldosterone

Adrenal cortex

What is the overall effect of RAAS?

. Increase blood pressure

What happens to blood pressure when blood vessels constrict

It increases

Aldosterone causes the body to retain

Na⁺

What happens to water when Na⁺ is retained?

Water is also retained

ADH mainly causes increased:

Water retention

. When blood pressure and Na⁺ levels return to normal, what happens to renin secretion?

It decreases/stops

What happens to ADH when body hydration decreases?

ADH increases

Which part of the brain signals for ADH release?

where is ADH released from

Hypothalamus

its released from posterior pituitary

ADH causes the distal convoluted tubules and collecting ducts to:

Increase water reabsorption, water is reabsorbed by Osmosis

what happens to Urine volume when ADH increased and decrease

Increased → decrease urine volume and it become concentrated

decreased → increased urine volume and diluted