DDI (drug drug interaction)

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Last updated 6:24 AM on 8/26/26
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6 Terms

1
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Nitrates (nitroglycerin, isosorbide di/mononitrate) + PDE5 inhibitors (-afil)

Fatal hypotension [both produce additive vasodilation.]

2
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Warfarin + NSAIDs or Aspirin

Severe bleeding risk GI hemorrhage [both increase bleeding risk; NSAID damage stomach lining]

3
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Opioids + benzodiazepines

respiratory depression, coma, death [additive CNS and respiratory depression]

4
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ACE inhibitors + ksparing diuretics

Hyperkalemia [can trigger cardiac arrhythmias and arrest]

5
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MAOIs + SSRIs

Serotonin syndrome

6
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Fluoroquinolones + multivalent cations (antacids with ca2+…)

treatment failure [cations bind the antibiotic, preventing intestinal absorption]