PHOSPHODIESTERASE TYPE 5 INHIBITORS

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5 Terms

1
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what are the Phosphodiesterase Type 5 Inhibitors?

-fil

  • sildenafil

  • tadalafil

  • vardenafil

  • avanafil

2
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what is the mechanism of action for Phosphodiesterase Type 5 Inhibitors?

  • vasodilation properties

  • enhances normal erectile response to sexual stimuli and leads to more rigid and longer lasting erection

    • if there is no sexual stimulus, no physiologic response occurs

3
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what are the indications for Phosphodiesterase Type 5 Inhibitors?

  • erectile dysfunction

  • pulmonary hypertension

  • BPH

4
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what are adverse effects of Phosphodiesterase Type 5 Inhibitors?

  • flushing

  • headache

  • hypotension

  • blue discoloration of vision

  • hearing loss

  • priapism

    • painful erection lasting >6 hrs

    • seek help if >4 hrs

5
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what are intervention for Phosphodiesterase Type 5 Inhibitors?

  • use with caution with angina pectoris

    • avoid admin within 24-48 hrs of nitrates due to hypotension

  • do not concurrently use with adrenergic antagonists (terazosin, doxazosin) due to hypotension